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• W2080449949 abstract "The effect of the acute i.p. administration of lithium chloride (1 mg/kg) and of haloperidol (1 mg/kg) on retinal melatonin levels was studied in light-adapted and dark-adapted frogs of the species Rana esculenta. Two hours following drug administration, animals were killed by decapitation and a single retina from each frog was collected and homogenized in 1 ml of chilled 0.1 N HCl. After centrifugation, the pH of the supernatant was adjusted to 7.0. Melatonin was extracted by diethylether and assayed by double antibody radioimmunoassay (RIA). Lithium induced a significant decrease of retinal melatonin levels both in light-adapted (P < 0.006) and in dark-adapted (P < 0.01) animals, whercas no change was observed after haloperidol treatment. These results suggest that the scleral aggregation of pigment granules induced by lithium in the frog retina is not mediated by a stimulation of melatonin synthesis." @default.
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• W2080449949 date "1989-01-01" @default.
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• W2080449949 title "Lithium decreases retinal melatonin levels in the frog" @default.
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• W2080449949 doi "https://doi.org/10.1016/0304-3940(89)90064-5" @default.
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