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- W2080450089 abstract "Abstract Heat measurements were found to provide a quantitative assay of phagocytosis in which there is a dramatic increase in heat production. Glycyrrhizin, an extract from Glycyrrhizaglabra, has a beneficial effect on patients with viral infections including hepatitis and AIDS. Therefore the in vivo effect of glycyrrhizin on the phagocytic function of blood neutrophils in rats was investigated. Glycyrrhizin was injected in vivo into rats twice a day for 2 days and the blood was taken from the descending aorta. Neutrophils were isolated and the phagocytic function was determined both by heat production using a thermoactive cell analyser (ESCO 3000) and by the conventional assay system using Saccharomyces cerevisiae. In vivo treatment of glycyrrhizin seemed to enhance heat production by 40% during phagocytosis, as compared with neutrophils from non-treated rats. However, it was not possible to detect this difference using the conventional assay system in which small functional changes cannot be determined. Therefore microcalorimetry can provide clear evidence of a small change in cell function and may lead to a new field in cell biology." @default.
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- W2080450089 date "1991-07-01" @default.
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- W2080450089 title "Heat production is a quantitative parameter for intracellular cell function" @default.
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- W2080450089 doi "https://doi.org/10.1016/0040-6031(91)80460-z" @default.
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