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- W2080450179 abstract "The risk of antibody-dependent enhancement (ADE) of dengue virus (DENV) infection is a major obstacle for the development of dengue vaccine candidates. Here, we described a novel approach for assessment of ADE by measuring DENV nonstructural protein 1 (NS1) production in culture supernatants with Fcγ receptor-expressing K562 cells in ELISA format (ELISA-ADE). Enhancing activities quantified by measurement of kinetics of NS1 production were in a good agreement with the results of the virus titration assay. In conjunction with the previously established enzyme-linked immunospot-based micro-neutralization test (ELISPOT-MNT) in 96-well format, the observable dose–response profiles of enhancing and neutralizing activities against all four DENV serotypes were produced with two flaviviral envelope cross-reactive monoclonal antibodies and four primary DENV-1-infected human sera. The simple high-throughput ELISA-ADE assay offers advantages for quantitative measurement of infection enhancement that can potentially be applied to large-scale seroepidemiological studies of DENV infection and vaccination." @default.
- W2080450179 created "2016-06-24" @default.
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- W2080450179 date "2013-06-12" @default.
- W2080450179 modified "2023-10-16" @default.
- W2080450179 title "Evaluation and analysis of dengue virus enhancing and neutralizing activities using simple high-throughput assays" @default.
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- W2080450179 doi "https://doi.org/10.1007/s00253-013-5021-8" @default.
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