Matches in SemOpenAlex for { <https://semopenalex.org/work/W2080450195> ?p ?o ?g. }
- W2080450195 endingPage "2239" @default.
- W2080450195 startingPage "2230" @default.
- W2080450195 abstract "Objectives: Catheter-based renal artery denervation has been successfully introduced as alternative treatment for patients suffering from drug-resistant essential hypertension. However, the local morphological changes within the vessel wall accompanying this technique remain elusive and we sought to characterize these by utilizing the simplicity radiofrequency catheter approach. Methods: Following treatment of seven pigs, renal arteries were assigned to either the acute (n = 6), subacute (10-day follow-up, n = 6) or control (untreated, n = 2) group. At follow-up blood analysis, final angiography and optical coherence tomography (OCT)-imaging of the treated arteries were performed and renal arteries and kidneys were processed for histopathology and immunohistochemistry. Results: Radiofrequency-derived energy application to the vessel wall induced transmural tissue coagulation and loss of endothelium resulting in local thrombus formation also detectable by OCT. At 10 days, the luminal surface was almost completely re-endothelialized. Mural wall damage was replaced by fibrotic tissue and the adventitial layer showed strong inflammatory infiltration including vasculogenesis. Remnant autonomic nerve fascicles within the lesion segments of the subacute group displayed enhanced vacuolic degeneration and an impaired neurofilament protein immunostaining pattern. Examination of the kidneys revealed no abnormalities and blood parameters remained within the physiological range. Conclusion: Catheter-based application of radiofrequency energy resulted in circumscribed transmural injury within the arterial wall affecting autonomic nerve fascicles delayed to treatment. Acute loss of endothelialization resulted in thrombus formation leaving kidney perfusion apparently unimpaired." @default.
- W2080450195 created "2016-06-24" @default.
- W2080450195 creator A5024423881 @default.
- W2080450195 creator A5048924859 @default.
- W2080450195 creator A5057050688 @default.
- W2080450195 creator A5059651131 @default.
- W2080450195 creator A5061892606 @default.
- W2080450195 creator A5065655858 @default.
- W2080450195 creator A5075829336 @default.
- W2080450195 creator A5085332426 @default.
- W2080450195 creator A5091776005 @default.
- W2080450195 date "2012-11-01" @default.
- W2080450195 modified "2023-10-06" @default.
- W2080450195 title "Morphological assessment of renal arteries after radiofrequency catheter-based sympathetic denervation in a porcine model" @default.
- W2080450195 cites W1966557081 @default.
- W2080450195 cites W1980143386 @default.
- W2080450195 cites W1991427110 @default.
- W2080450195 cites W1994487234 @default.
- W2080450195 cites W1999969246 @default.
- W2080450195 cites W2018506246 @default.
- W2080450195 cites W2027327022 @default.
- W2080450195 cites W2046492769 @default.
- W2080450195 cites W2060989550 @default.
- W2080450195 cites W2062146353 @default.
- W2080450195 cites W2075471944 @default.
- W2080450195 cites W2095652178 @default.
- W2080450195 cites W2115461708 @default.
- W2080450195 cites W2122915712 @default.
- W2080450195 cites W2138908243 @default.
- W2080450195 cites W2170564896 @default.
- W2080450195 cites W2321657043 @default.
- W2080450195 cites W4253237537 @default.
- W2080450195 doi "https://doi.org/10.1097/hjh.0b013e32835821e5" @default.
- W2080450195 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22914572" @default.
- W2080450195 hasPublicationYear "2012" @default.
- W2080450195 type Work @default.
- W2080450195 sameAs 2080450195 @default.
- W2080450195 citedByCount "89" @default.
- W2080450195 countsByYear W20804501952012 @default.
- W2080450195 countsByYear W20804501952013 @default.
- W2080450195 countsByYear W20804501952014 @default.
- W2080450195 countsByYear W20804501952015 @default.
- W2080450195 countsByYear W20804501952016 @default.
- W2080450195 countsByYear W20804501952017 @default.
- W2080450195 countsByYear W20804501952018 @default.
- W2080450195 countsByYear W20804501952019 @default.
- W2080450195 countsByYear W20804501952020 @default.
- W2080450195 countsByYear W20804501952021 @default.
- W2080450195 crossrefType "journal-article" @default.
- W2080450195 hasAuthorship W2080450195A5024423881 @default.
- W2080450195 hasAuthorship W2080450195A5048924859 @default.
- W2080450195 hasAuthorship W2080450195A5057050688 @default.
- W2080450195 hasAuthorship W2080450195A5059651131 @default.
- W2080450195 hasAuthorship W2080450195A5061892606 @default.
- W2080450195 hasAuthorship W2080450195A5065655858 @default.
- W2080450195 hasAuthorship W2080450195A5075829336 @default.
- W2080450195 hasAuthorship W2080450195A5085332426 @default.
- W2080450195 hasAuthorship W2080450195A5091776005 @default.
- W2080450195 hasConcept C105702510 @default.
- W2080450195 hasConcept C126322002 @default.
- W2080450195 hasConcept C126838900 @default.
- W2080450195 hasConcept C142724271 @default.
- W2080450195 hasConcept C146957229 @default.
- W2080450195 hasConcept C164705383 @default.
- W2080450195 hasConcept C2776634560 @default.
- W2080450195 hasConcept C2776805190 @default.
- W2080450195 hasConcept C2780091579 @default.
- W2080450195 hasConcept C2781362458 @default.
- W2080450195 hasConcept C71924100 @default.
- W2080450195 hasConceptScore W2080450195C105702510 @default.
- W2080450195 hasConceptScore W2080450195C126322002 @default.
- W2080450195 hasConceptScore W2080450195C126838900 @default.
- W2080450195 hasConceptScore W2080450195C142724271 @default.
- W2080450195 hasConceptScore W2080450195C146957229 @default.
- W2080450195 hasConceptScore W2080450195C164705383 @default.
- W2080450195 hasConceptScore W2080450195C2776634560 @default.
- W2080450195 hasConceptScore W2080450195C2776805190 @default.
- W2080450195 hasConceptScore W2080450195C2780091579 @default.
- W2080450195 hasConceptScore W2080450195C2781362458 @default.
- W2080450195 hasConceptScore W2080450195C71924100 @default.
- W2080450195 hasIssue "11" @default.
- W2080450195 hasLocation W20804501951 @default.
- W2080450195 hasLocation W20804501952 @default.
- W2080450195 hasOpenAccess W2080450195 @default.
- W2080450195 hasPrimaryLocation W20804501951 @default.
- W2080450195 hasRelatedWork W1982332223 @default.
- W2080450195 hasRelatedWork W2025519350 @default.
- W2080450195 hasRelatedWork W2027630017 @default.
- W2080450195 hasRelatedWork W2142081317 @default.
- W2080450195 hasRelatedWork W2343743485 @default.
- W2080450195 hasRelatedWork W2498688040 @default.
- W2080450195 hasRelatedWork W2587030079 @default.
- W2080450195 hasRelatedWork W2803381041 @default.
- W2080450195 hasRelatedWork W2940752283 @default.
- W2080450195 hasRelatedWork W3019031333 @default.
- W2080450195 hasVolume "30" @default.
- W2080450195 isParatext "false" @default.
- W2080450195 isRetracted "false" @default.