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• W2080451412 endingPage "286" @default.
• W2080451412 startingPage "267" @default.
• W2080451412 abstract "After cortical injury resulting from stroke, some recovery can occur and may involve spared areas of the cerebral cortex reorganizing to assume functions previously controlled by the damaged cortical areas. No studies have specifically assessed gene expression changes in remote neurons with axonal processes that terminate in the infarcted tissue, i.e., the subset of neurons most likely to be involved in regenerative processes. By physiologically identifying the primary motor area controlling forelimb function in adult rats (caudal forelimb area = CFA), and injecting a retrograde tract-tracer, we labeled neurons within the non-primary motor cortex (rostral forelimb area = RFA) that project to CFA. Then, 7 days after a CFA infarct (n = 6), we used laser capture microdissection techniques to harvest labeled neurons in RFA. Healthy, uninjured rats served as controls (n = 6). Biological interactions and functions of gene profiling were investigated by Affymetrix Microarray, and Ingenuity Pathway Analysis. A total of 143 up- and 128 down-regulated genes showed significant changes (fold change ≥1.3 and p < 0.05). The canonical pathway, “Axonal Guidance Signaling,” was overrepresented (p value = 0.002). Significantly overrepresented functions included: branching of neurites, organization of cytoskeleton, dendritic growth and branching, organization of cytoplasm, guidance of neurites, development of cellular protrusions, density of dendritic spines, and shape change (p = 0.000151–0.0487). As previous studies have shown that spared motor areas are important in recovery following injury to the primary motor area, the results suggest that these gene expression changes in remote, interconnected neurons may underlie reorganization and recovery mechanisms." @default.
• W2080451412 created "2016-06-24" @default.
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• W2080451412 date "2012-07-21" @default.
• W2080451412 modified "2023-09-26" @default.
• W2080451412 title "Gene expression changes of interconnected spared cortical neurons 7 days after ischemic infarct of the primary motor cortex in the rat" @default.
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• W2080451412 doi "https://doi.org/10.1007/s11010-012-1390-z" @default.
• W2080451412 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3694431" @default.
• W2080451412 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22821175" @default.
• W2080451412 hasPublicationYear "2012" @default.
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