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- W2080451697 abstract "Cerebrospinal fluid, from the cisterna magna of the rabbit, contains acetylcholinesterase which gives a single zone of activity upon gel electrophoresis. In contrast, blood plasma and the particle free supernatant of rabbit brain homogenate (0.3M sucrose) contain several isoenzymes of acetylcholinesterase, one of which has the same electrophoretic mobility as the isoenzyme in cerebrospinal fluid. Electrical stimulation of the central ends of cut peripheral nerves (sciatic and saphenous) in rabbits anaesthetised with urethane leads to an increase in the concentration of acetylcholinesterase activity in the cerebrospinal fluid, which reaches a maximum of 3 times the resting concentration about 100 min after the end of the stimulation period. The rise in the level of acetylcholinesterase is accounted for by an increased concentration of the single isoenzyme characteristic of cerebrospinal fluid. The specific activity of the acetylcholinesterase per weight of protein in the cerebrospinal fluid is at all times many times higher than that in blood plasma. There is no change in the lactate dehydrogenase and potassium ion concentrations in the cerebrospinal fluid following sensory nerve stimulation. We consider that the increase in the concentration of acetylcholinesterase in the cerebrospinal fluid is unlikely to be the result either of a breakdown in the blood-cerebrospinal fluid barrier or of pathological damage to central neurons. A possible explanation for our observations is that acetylcholinesterase-containing neurons might secrete one of the isoenzymes into the extracellular space, from where it passes into the cerebrospinal fluid." @default.
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- W2080451697 date "1976-01-01" @default.
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- W2080451697 title "Is acetylcholinesterase secreted from central neurons into the cerebrospinal fluid?" @default.
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- W2080451697 doi "https://doi.org/10.1016/0306-4522(76)90048-8" @default.
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