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- W2080452349 abstract "SUMMARY Analogue techniques were applied to measurements of phasic aortic blood flow and pressure to obtain continuous recordings of peripheral vascular resistance and circulatory function in open-chest dogs during basal narcosis with chloralose. Whereas the hypotension following hexamethonium 1 and 3 mg/kg i.v. was associated with a marked fall in peripheral vascular resistance and some reduction of maximum acceleration and cardiac output, the hypotension during ventilation with 1 and 2% halothane was associated with a large reduction in maximum acceleration (i.e. cardiac depression) and cardiac output with a relatively small fall in peripheral vascular resistance. In closed-chest dogs 1–2% halothane caused falls in arterial blood pressure and heart rate similar to those after hexamethonium 1–3 mg/kg i.v. without comparable impairment of either vagally-induced bradycardia or the contractions of the nictitating membrane due to sympathetic nerve stimulation. Ganglion blockade did, however, become prominent with concentrations of 4% halothane. It is thought that diminished central vasomotor tone, a reduction of the effects of the sympathetic mediator on blood vessels and a direct relaxant effect of halothane on vascular smooth muscle also contribute importantly to the peripheral vascular depression." @default.
- W2080452349 created "2016-06-24" @default.
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- W2080452349 date "1973-05-01" @default.
- W2080452349 modified "2023-10-18" @default.
- W2080452349 title "THE HAEMODYNAMIC EFFECTS OF HALOTHANE IN DOGS" @default.
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- W2080452349 doi "https://doi.org/10.1093/bja/45.5.416" @default.
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