FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2080452542> ?p ?o ?g. }

• W2080452542 endingPage "A308" @default.
• W2080452542 startingPage "A308" @default.
• W2080452542 abstract "To develop a quantitative process to estimate the probability of a favorable assessment of additional clinical benefit for a new drug for a chronic non-life threatening disease in Germany A multi-criteria decision process was use that included: selection of 7 German decision makers; pre-workshop questionnaires to identify the most important attributes for the decision and their relative importance; a workshop to develop levels for the most important attributes, map each attribute level to a value function and identify marginal drug profiles (drugs just demonstrating ‘additional clinical benefit'); post-workshop estimation of weighted scores for each marginal product based on the estimated values and relative importance of their attribute levels and a logistic regression model to estimate the probability of an ‘additional clinical benefit' decision as a function of the weighted scores; post-workshop questionnaire to validate the logistic regression model using participant ratings for some hypothetical products. The most important attributes identified for a determination of ‘additional clinical benefit' and their relative importance weights (%) were: robustness of clinical evidence (29%); incremental efficacy (19%); unmet need (12%); incremental impact on QOL (10%); availability of alternative treatments (9%); safety of new drug (9%); burden of disease (5%); availability of other country evaluations (4%); budget impact (3%). The attribute levels and relative value for a positive decision (0-1) for the most important attribute, robustness of clinical evidence, were: ‘endpoints and/or comparators not relevant to patients' (0); ‘clinical endpoints relevant but comparators not relevant needing indirect comparisons' (0.764); and ‘all clinical endpoints and comparators relevant for patients and payers (1)'. The estimates of the probability of an ‘additional clinical benefit' for the hypothetical products using the logistic regression model had 71% positive predictive value and 85% negative predictive value when compared to participant decisions for these hypothetical products. An MCDA process can provide both a qualitative understanding and quantitative estimates of the relative importance, attribute levels, and value scales of different product attributes that influence a decision of ‘additional clinical benefit' in Germany." @default.
• W2080452542 created "2016-06-24" @default.
• W2080452542 creator A5026996902 @default.
• W2080452542 creator A5032122609 @default.
• W2080452542 creator A5068655389 @default.
• W2080452542 creator A5085070252 @default.
• W2080452542 date "2012-11-01" @default.
• W2080452542 modified "2023-09-29" @default.
• W2080452542 title "PHP112 Estimating the Probability of a Favorable Assessment of Clinical Benefits for a New Drug in Germany Using an MCDA Approach" @default.
• W2080452542 doi "https://doi.org/10.1016/j.jval.2012.08.654" @default.
• W2080452542 hasPublicationYear "2012" @default.
• W2080452542 type Work @default.
• W2080452542 sameAs 2080452542 @default.
• W2080452542 citedByCount "0" @default.
• W2080452542 crossrefType "journal-article" @default.
• W2080452542 hasAuthorship W2080452542A5026996902 @default.
• W2080452542 hasAuthorship W2080452542A5032122609 @default.
• W2080452542 hasAuthorship W2080452542A5068655389 @default.
• W2080452542 hasAuthorship W2080452542A5085070252 @default.
• W2080452542 hasBestOaLocation W20804525421 @default.
• W2080452542 hasConcept C104317684 @default.
• W2080452542 hasConcept C105795698 @default.
• W2080452542 hasConcept C11105738 @default.
• W2080452542 hasConcept C126322002 @default.
• W2080452542 hasConcept C151956035 @default.
• W2080452542 hasConcept C185592680 @default.
• W2080452542 hasConcept C33923547 @default.
• W2080452542 hasConcept C42475967 @default.
• W2080452542 hasConcept C55493867 @default.
• W2080452542 hasConcept C63479239 @default.
• W2080452542 hasConcept C71924100 @default.
• W2080452542 hasConceptScore W2080452542C104317684 @default.
• W2080452542 hasConceptScore W2080452542C105795698 @default.
• W2080452542 hasConceptScore W2080452542C11105738 @default.
• W2080452542 hasConceptScore W2080452542C126322002 @default.
• W2080452542 hasConceptScore W2080452542C151956035 @default.
• W2080452542 hasConceptScore W2080452542C185592680 @default.
• W2080452542 hasConceptScore W2080452542C33923547 @default.
• W2080452542 hasConceptScore W2080452542C42475967 @default.
• W2080452542 hasConceptScore W2080452542C55493867 @default.
• W2080452542 hasConceptScore W2080452542C63479239 @default.
• W2080452542 hasConceptScore W2080452542C71924100 @default.
• W2080452542 hasIssue "7" @default.
• W2080452542 hasLocation W20804525421 @default.
• W2080452542 hasOpenAccess W2080452542 @default.
• W2080452542 hasPrimaryLocation W20804525421 @default.
• W2080452542 hasRelatedWork W1985231403 @default.
• W2080452542 hasRelatedWork W2011915929 @default.
• W2080452542 hasRelatedWork W2037668591 @default.
• W2080452542 hasRelatedWork W2046857079 @default.
• W2080452542 hasRelatedWork W2070601272 @default.
• W2080452542 hasRelatedWork W2347937125 @default.
• W2080452542 hasRelatedWork W2389709268 @default.
• W2080452542 hasRelatedWork W2553734051 @default.
• W2080452542 hasRelatedWork W2623430991 @default.
• W2080452542 hasRelatedWork W3126658412 @default.
• W2080452542 hasVolume "15" @default.
• W2080452542 isParatext "false" @default.
• W2080452542 isRetracted "false" @default.
• W2080452542 magId "2080452542" @default.
• W2080452542 workType "article" @default.