FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2080453616> ?p ?o ?g. }

• W2080453616 endingPage "1388" @default.
• W2080453616 startingPage "1379" @default.
• W2080453616 abstract "Virologic rebound can result from suboptimal antiviral potency in combination antiretroviral therapy.Multicenter, partially blinded, prospective, randomized study of 202 HIV-infected subjects to determine whether therapy intensification improves long-term rates of virologic suppression.Subjects had plasma HIV RNA < 200 copies/ml, CD4 cell count of > 200 x 10(6) cells/l, and treatment with indinavir (IDV) + zidovudine (ZDV) + lamivudine (3TC) for at least 6 months before randomization to stay on this regimen or to receive IDV + didanosine (ddI) + stavudine (d4T) plus or minus hydroxyurea (HU) (600 mg twice daily). Treatment failure was defined as either confirmed rebound of HIV RNA level to > 200 copies/ml or a drug toxicity necessitating treatment discontinuation.Treatment failure occurred more frequently in subjects randomized to the HU-containing arm (32.4%), than in those taking IDV + ddI + d4T (17.6%) or IDV + ZDV + 3TC (7.6%). The time to treatment failure was shorter for the HU-containing arm compared with the IDV + ZDV + 3TC (P < 0.0001) or IDV + ddI + d4T arms (P = 0.032). Dose-limiting toxicities rather than virologic rebound accounted for the differences between treatment failure among the study arms. Pancreatitis led to treatment discontinuation in 4% of subjects in treatment arms containing ddI + d4T. Three subjects with pancreatitis died, all randomized to the HU-containing arm.Switching to IDV + ddI + d4T + HU in patients treated with IDV + ZDV + 3TC was associated with a worse outcome, principally because of drug toxicity." @default.
• W2080453616 created "2016-06-24" @default.
• W2080453616 creator A5012623658 @default.
• W2080453616 creator A5027170980 @default.
• W2080453616 creator A5027211575 @default.
• W2080453616 creator A5043264519 @default.
• W2080453616 creator A5061630637 @default.
• W2080453616 creator A5069551580 @default.
• W2080453616 creator A5073322790 @default.
• W2080453616 creator A5085731242 @default.
• W2080453616 creator A5087290551 @default.
• W2080453616 creator A5089514918 @default.
• W2080453616 creator A5089772409 @default.
• W2080453616 creator A5090348690 @default.
• W2080453616 date "2001-07-01" @default.
• W2080453616 modified "2023-09-23" @default.
• W2080453616 title "Effects of treatment intensification with hydroxyurea in HIV-infected patients with virologic suppression" @default.
• W2080453616 cites W1986859702 @default.
• W2080453616 cites W2012139740 @default.
• W2080453616 cites W2027716154 @default.
• W2080453616 cites W2033939669 @default.
• W2080453616 cites W2034760164 @default.
• W2080453616 cites W2058563502 @default.
• W2080453616 cites W2062873183 @default.
• W2080453616 cites W2064280112 @default.
• W2080453616 cites W2099169775 @default.
• W2080453616 cites W2130305699 @default.
• W2080453616 cites W2133315239 @default.
• W2080453616 cites W2140984910 @default.
• W2080453616 cites W2156739085 @default.
• W2080453616 cites W2160676835 @default.
• W2080453616 cites W2164099498 @default.
• W2080453616 cites W2170219825 @default.
• W2080453616 cites W2171141994 @default.
• W2080453616 cites W2313623892 @default.
• W2080453616 cites W2317252918 @default.
• W2080453616 cites W2321852728 @default.
• W2080453616 cites W2325369502 @default.
• W2080453616 cites W2329393410 @default.
• W2080453616 cites W2337376130 @default.
• W2080453616 cites W2404250260 @default.
• W2080453616 doi "https://doi.org/10.1097/00002030-200107270-00007" @default.
• W2080453616 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11504959" @default.
• W2080453616 hasPublicationYear "2001" @default.
• W2080453616 type Work @default.
• W2080453616 sameAs 2080453616 @default.
• W2080453616 citedByCount "70" @default.
• W2080453616 countsByYear W20804536162013 @default.
• W2080453616 countsByYear W20804536162015 @default.
• W2080453616 countsByYear W20804536162016 @default.
• W2080453616 countsByYear W20804536162018 @default.
• W2080453616 countsByYear W20804536162020 @default.
• W2080453616 crossrefType "journal-article" @default.
• W2080453616 hasAuthorship W2080453616A5012623658 @default.
• W2080453616 hasAuthorship W2080453616A5027170980 @default.
• W2080453616 hasAuthorship W2080453616A5027211575 @default.
• W2080453616 hasAuthorship W2080453616A5043264519 @default.
• W2080453616 hasAuthorship W2080453616A5061630637 @default.
• W2080453616 hasAuthorship W2080453616A5069551580 @default.
• W2080453616 hasAuthorship W2080453616A5073322790 @default.
• W2080453616 hasAuthorship W2080453616A5085731242 @default.
• W2080453616 hasAuthorship W2080453616A5087290551 @default.
• W2080453616 hasAuthorship W2080453616A5089514918 @default.
• W2080453616 hasAuthorship W2080453616A5089772409 @default.
• W2080453616 hasAuthorship W2080453616A5090348690 @default.
• W2080453616 hasBestOaLocation W20804536161 @default.
• W2080453616 hasConcept C126322002 @default.
• W2080453616 hasConcept C142462285 @default.
• W2080453616 hasConcept C203014093 @default.
• W2080453616 hasConcept C2522874641 @default.
• W2080453616 hasConcept C2776452011 @default.
• W2080453616 hasConcept C2777210460 @default.
• W2080453616 hasConcept C2777447569 @default.
• W2080453616 hasConcept C2777869810 @default.
• W2080453616 hasConcept C2778715236 @default.
• W2080453616 hasConcept C2779889181 @default.
• W2080453616 hasConcept C2780216070 @default.
• W2080453616 hasConcept C2780593183 @default.
• W2080453616 hasConcept C2780727368 @default.
• W2080453616 hasConcept C2781413609 @default.
• W2080453616 hasConcept C3013748606 @default.
• W2080453616 hasConcept C71924100 @default.
• W2080453616 hasConcept C90924648 @default.
• W2080453616 hasConceptScore W2080453616C126322002 @default.
• W2080453616 hasConceptScore W2080453616C142462285 @default.
• W2080453616 hasConceptScore W2080453616C203014093 @default.
• W2080453616 hasConceptScore W2080453616C2522874641 @default.
• W2080453616 hasConceptScore W2080453616C2776452011 @default.
• W2080453616 hasConceptScore W2080453616C2777210460 @default.
• W2080453616 hasConceptScore W2080453616C2777447569 @default.
• W2080453616 hasConceptScore W2080453616C2777869810 @default.
• W2080453616 hasConceptScore W2080453616C2778715236 @default.
• W2080453616 hasConceptScore W2080453616C2779889181 @default.
• W2080453616 hasConceptScore W2080453616C2780216070 @default.
• W2080453616 hasConceptScore W2080453616C2780593183 @default.
• W2080453616 hasConceptScore W2080453616C2780727368 @default.
• W2080453616 hasConceptScore W2080453616C2781413609 @default.
• W2080453616 hasConceptScore W2080453616C3013748606 @default.

• next