Matches in SemOpenAlex for { <https://semopenalex.org/work/W2080453664> ?p ?o ?g. }
Showing items 1 to 98 of
98
with 100 items per page.
- W2080453664 endingPage "1253" @default.
- W2080453664 startingPage "1245" @default.
- W2080453664 abstract "Objectives . The goal of this study was to demonstrate myocardial infarct extension during reperfusion within the same animal. Background . Whether myocardial reperfusion can result in the extension of myocardial necrosis remains controversial. The transformation of reversibly injured myocytes into irreversibly damaged cells after reperfusion has been difficult to demonstrate pathologically. Methods . New Zealand White rabbits (Group I, n = 10) were subjected to 30 min of coronary artery occlusion and 180 min of reperfusion. Horseradish peroxidase, a tracer protein that permeates the sarcolemma of irreversibly injured myocytes, was used to quantitate myocyte necrosis at the beginning of reperfusion. Within the same heart, infarct size was measured after 180 min of reperfusion by triphenyttetrazolium chloride (TTC) staining. In separate experiments to demonstrate the validity of the model, rabbits were subjected to 30 min of coronary occlusion, followed by intravenous infusion of horseradish peroxidase and rapid induction of death (Group II) or 30 min of occlusion, 180 min of reperfusion with horseradish peroxidase administered after 180 min of reperfusion and TTC staining after induced death (Group III). Results . In Group I, infarct size at the onset of reperfusion, delineated by horseradish peroxidase, measured 45.3 ± 2.8% of the area of risk and was significantly less than TTC-delineated infarct size after 189 min of re perfusion (59.8 ± 33%, p = 0.0002). By electron microscopy, border areas within the ischemic bed demonstrated irreversibly injured horseradish peroxidasepositive myocytes adjacent to irreversibly injured horseradish peroxidase-negative myocytes, suggesting that farther cell death occurred during reperfusion. In Group II, infarcts delineated by horseradish peroxidase after 30 min of coronary occlusion were similar in size to infarcts measured by this tracer in Group I. In Group III, infarcts delineated by horseradish peroxidase at 180 min of reperfusion were similar in size to infarcts measured by TTC and similar to TTC-delineated infarcts measured at 180 min of reperfusion in Group I. Conclusions . These results provide evidence that there is a subset of myocytes in border areas within the ischemic region that are viable at the beginning of reperfusion but subsequently progress to irreversible injury during the reperfusion period." @default.
- W2080453664 created "2016-06-24" @default.
- W2080453664 creator A5019383658 @default.
- W2080453664 creator A5027049498 @default.
- W2080453664 creator A5068524141 @default.
- W2080453664 creator A5071287538 @default.
- W2080453664 date "1993-04-01" @default.
- W2080453664 modified "2023-09-24" @default.
- W2080453664 title "Myocardial infarct extension during reperfusion after coronary artery occlusion: Pathologic evidence" @default.
- W2080453664 cites W1965001072 @default.
- W2080453664 cites W2001898552 @default.
- W2080453664 cites W2003104658 @default.
- W2080453664 cites W2007597631 @default.
- W2080453664 cites W2016233351 @default.
- W2080453664 cites W2017980806 @default.
- W2080453664 cites W2035112691 @default.
- W2080453664 cites W2041376695 @default.
- W2080453664 cites W2058618439 @default.
- W2080453664 cites W2063448257 @default.
- W2080453664 cites W2073702336 @default.
- W2080453664 cites W2075206212 @default.
- W2080453664 cites W2080564870 @default.
- W2080453664 cites W2081123268 @default.
- W2080453664 cites W2088252933 @default.
- W2080453664 cites W2103924942 @default.
- W2080453664 cites W2129042092 @default.
- W2080453664 cites W2129179416 @default.
- W2080453664 cites W2132171326 @default.
- W2080453664 cites W2134732656 @default.
- W2080453664 cites W2143353805 @default.
- W2080453664 cites W2156514272 @default.
- W2080453664 cites W2409500270 @default.
- W2080453664 doi "https://doi.org/10.1016/0735-1097(93)90253-w" @default.
- W2080453664 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8459084" @default.
- W2080453664 hasPublicationYear "1993" @default.
- W2080453664 type Work @default.
- W2080453664 sameAs 2080453664 @default.
- W2080453664 citedByCount "107" @default.
- W2080453664 countsByYear W20804536642012 @default.
- W2080453664 countsByYear W20804536642013 @default.
- W2080453664 countsByYear W20804536642016 @default.
- W2080453664 countsByYear W20804536642017 @default.
- W2080453664 countsByYear W20804536642022 @default.
- W2080453664 crossrefType "journal-article" @default.
- W2080453664 hasAuthorship W2080453664A5019383658 @default.
- W2080453664 hasAuthorship W2080453664A5027049498 @default.
- W2080453664 hasAuthorship W2080453664A5068524141 @default.
- W2080453664 hasAuthorship W2080453664A5071287538 @default.
- W2080453664 hasConcept C126322002 @default.
- W2080453664 hasConcept C146957229 @default.
- W2080453664 hasConcept C164705383 @default.
- W2080453664 hasConcept C181199279 @default.
- W2080453664 hasConcept C185592680 @default.
- W2080453664 hasConcept C207200792 @default.
- W2080453664 hasConcept C2776268601 @default.
- W2080453664 hasConcept C2777676563 @default.
- W2080453664 hasConcept C2777798775 @default.
- W2080453664 hasConcept C2780393670 @default.
- W2080453664 hasConcept C500558357 @default.
- W2080453664 hasConcept C503630168 @default.
- W2080453664 hasConcept C55493867 @default.
- W2080453664 hasConcept C71924100 @default.
- W2080453664 hasConceptScore W2080453664C126322002 @default.
- W2080453664 hasConceptScore W2080453664C146957229 @default.
- W2080453664 hasConceptScore W2080453664C164705383 @default.
- W2080453664 hasConceptScore W2080453664C181199279 @default.
- W2080453664 hasConceptScore W2080453664C185592680 @default.
- W2080453664 hasConceptScore W2080453664C207200792 @default.
- W2080453664 hasConceptScore W2080453664C2776268601 @default.
- W2080453664 hasConceptScore W2080453664C2777676563 @default.
- W2080453664 hasConceptScore W2080453664C2777798775 @default.
- W2080453664 hasConceptScore W2080453664C2780393670 @default.
- W2080453664 hasConceptScore W2080453664C500558357 @default.
- W2080453664 hasConceptScore W2080453664C503630168 @default.
- W2080453664 hasConceptScore W2080453664C55493867 @default.
- W2080453664 hasConceptScore W2080453664C71924100 @default.
- W2080453664 hasIssue "5" @default.
- W2080453664 hasLocation W20804536641 @default.
- W2080453664 hasLocation W20804536642 @default.
- W2080453664 hasOpenAccess W2080453664 @default.
- W2080453664 hasPrimaryLocation W20804536641 @default.
- W2080453664 hasRelatedWork W1999040834 @default.
- W2080453664 hasRelatedWork W2005658197 @default.
- W2080453664 hasRelatedWork W2045745727 @default.
- W2080453664 hasRelatedWork W2052519799 @default.
- W2080453664 hasRelatedWork W2068259322 @default.
- W2080453664 hasRelatedWork W2085567467 @default.
- W2080453664 hasRelatedWork W2125712784 @default.
- W2080453664 hasRelatedWork W2411409993 @default.
- W2080453664 hasRelatedWork W3174623225 @default.
- W2080453664 hasRelatedWork W4290352547 @default.
- W2080453664 hasVolume "21" @default.
- W2080453664 isParatext "false" @default.
- W2080453664 isRetracted "false" @default.
- W2080453664 magId "2080453664" @default.
- W2080453664 workType "article" @default.