Matches in SemOpenAlex for { <https://semopenalex.org/work/W2080453925> ?p ?o ?g. }
- W2080453925 endingPage "172" @default.
- W2080453925 startingPage "157" @default.
- W2080453925 abstract "Various micro-organisms are able to use sterols/steroids as carbon- and energy sources for growth. 3-Ketosteroid 9α-hydroxylase (KSH), a two component Rieske non-heme monooxygenase comprised of the oxygenase KshA and the reductase KshB, is a key-enzyme in bacterial steroid degradation. It initiates opening of the steroid polycyclic ring structure. The enzyme has industrial relevance in the synthesis of pharmaceutical steroids. Deletion of KSH activity in sterol degrading bacteria results in blockage of steroid ring opening and is used to produce valuable C19-steroids such as 4-androstene-3,17-dione and 1,4-androstadiene-3,17-dione. Interestingly, KSH activity is essential for the pathogenicity of Mycobacterium tuberculosis. Detailed information about KSH thus is of medical relevance, and KSH inhibitory compounds may find application in combatting tuberculosis. In recent years, the 3D structure of the KshA protein of M. tuberculosis H37Rv has been elucidated and various studies report biochemical characteristics and possible physiological roles of KSH. The current knowledge is reviewed here and forms a solid basis for further studies on this highly interesting enzyme. Future work may result in the construction of KSH mutants capable of production of specific bioactive steroids. Furthermore, KSH provides an promising target for drugs against the pathogenic agent M. tuberculosis." @default.
- W2080453925 created "2016-06-24" @default.
- W2080453925 creator A5007499849 @default.
- W2080453925 creator A5034787315 @default.
- W2080453925 creator A5063760369 @default.
- W2080453925 date "2014-05-21" @default.
- W2080453925 modified "2023-10-18" @default.
- W2080453925 title "3-Ketosteroid 9α-hydroxylase enzymes: Rieske non-heme monooxygenases essential for bacterial steroid degradation" @default.
- W2080453925 cites W1539787751 @default.
- W2080453925 cites W1593587637 @default.
- W2080453925 cites W1621884619 @default.
- W2080453925 cites W1777975588 @default.
- W2080453925 cites W1839665474 @default.
- W2080453925 cites W1857087500 @default.
- W2080453925 cites W1963974108 @default.
- W2080453925 cites W1964749004 @default.
- W2080453925 cites W1964796427 @default.
- W2080453925 cites W1969989079 @default.
- W2080453925 cites W1972675724 @default.
- W2080453925 cites W1981580562 @default.
- W2080453925 cites W1987282679 @default.
- W2080453925 cites W1988062176 @default.
- W2080453925 cites W1990951667 @default.
- W2080453925 cites W1991233072 @default.
- W2080453925 cites W1994613310 @default.
- W2080453925 cites W1996413959 @default.
- W2080453925 cites W1999845779 @default.
- W2080453925 cites W2001638922 @default.
- W2080453925 cites W2002748520 @default.
- W2080453925 cites W2005283437 @default.
- W2080453925 cites W2007097682 @default.
- W2080453925 cites W2011412696 @default.
- W2080453925 cites W2012401997 @default.
- W2080453925 cites W2012942844 @default.
- W2080453925 cites W2015363824 @default.
- W2080453925 cites W2017529053 @default.
- W2080453925 cites W2020100815 @default.
- W2080453925 cites W2020108475 @default.
- W2080453925 cites W2034114423 @default.
- W2080453925 cites W2036378326 @default.
- W2080453925 cites W2039870148 @default.
- W2080453925 cites W2040432888 @default.
- W2080453925 cites W2046473371 @default.
- W2080453925 cites W2047510552 @default.
- W2080453925 cites W2054665082 @default.
- W2080453925 cites W2055042385 @default.
- W2080453925 cites W2055611989 @default.
- W2080453925 cites W2056511259 @default.
- W2080453925 cites W2059042455 @default.
- W2080453925 cites W2061410357 @default.
- W2080453925 cites W2065166675 @default.
- W2080453925 cites W2072042071 @default.
- W2080453925 cites W2072433756 @default.
- W2080453925 cites W2073170899 @default.
- W2080453925 cites W2074910209 @default.
- W2080453925 cites W2075417405 @default.
- W2080453925 cites W2078290295 @default.
- W2080453925 cites W2080324161 @default.
- W2080453925 cites W2080553952 @default.
- W2080453925 cites W2081627226 @default.
- W2080453925 cites W2082315404 @default.
- W2080453925 cites W2084627980 @default.
- W2080453925 cites W2086780915 @default.
- W2080453925 cites W2091382386 @default.
- W2080453925 cites W2093363647 @default.
- W2080453925 cites W2099256964 @default.
- W2080453925 cites W2101648876 @default.
- W2080453925 cites W2101747551 @default.
- W2080453925 cites W2102173385 @default.
- W2080453925 cites W2106487454 @default.
- W2080453925 cites W2107222513 @default.
- W2080453925 cites W2109118261 @default.
- W2080453925 cites W2110447523 @default.
- W2080453925 cites W2110500811 @default.
- W2080453925 cites W2114625219 @default.
- W2080453925 cites W2118940366 @default.
- W2080453925 cites W2119505174 @default.
- W2080453925 cites W2120100753 @default.
- W2080453925 cites W2121903666 @default.
- W2080453925 cites W2122757679 @default.
- W2080453925 cites W2125842439 @default.
- W2080453925 cites W2131816099 @default.
- W2080453925 cites W2132879814 @default.
- W2080453925 cites W2136317897 @default.
- W2080453925 cites W2140354550 @default.
- W2080453925 cites W2144151918 @default.
- W2080453925 cites W2145465690 @default.
- W2080453925 cites W2147049140 @default.
- W2080453925 cites W2147293395 @default.
- W2080453925 cites W2153549208 @default.
- W2080453925 cites W2153581359 @default.
- W2080453925 cites W2163523836 @default.
- W2080453925 cites W2170037274 @default.
- W2080453925 cites W2171617274 @default.
- W2080453925 cites W2171993759 @default.
- W2080453925 cites W2331527942 @default.
- W2080453925 cites W2338553664 @default.
- W2080453925 cites W4210933917 @default.