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- W2080454312 abstract "Although human and murine antibodies are similar when considering their diversification strategies, they differ in the proportion by which κ and λ type chains are present in their receptive VL repertoires. It has been shown that this difference implies a divergence in the structural repertoire of the κ and λ genes of these species. Nonetheless, the differences in VH have not been systematically studied. In this paper a systematic characterization of the Vh structural repertoire of mice is made, so that a comparison with the VH structural repertoire of humans, described in detail elsewhere, could be properly accomplished. Our study shows the structural repertoire of mice to be dominated by canoical structure class 1–2 (∼60%), while in humans the dominant one is class 1–3 (∼40%). Analysis of the evolutionary relationships between human and mice suggest that this divergence may have a functional meaning. The implications of such findings are discussed." @default.
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- W2080454312 date "1997-11-01" @default.
- W2080454312 modified "2023-10-01" @default.
- W2080454312 title "The differences between the structural repertoires of VH germ-line gene segments of mice and humans: Implication for the molecular mechanism of the immune response" @default.
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- W2080454312 doi "https://doi.org/10.1016/s0161-5890(97)00118-1" @default.
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