Matches in SemOpenAlex for { <https://semopenalex.org/work/W2080454950> ?p ?o ?g. }
- W2080454950 endingPage "2729" @default.
- W2080454950 startingPage "2720" @default.
- W2080454950 abstract "Establishing improved methods for the radiolabeling of peptides with fluorine-18 via solid-phase peptide synthesis (SPPS) is desirable for the efficient synthesis of peptide-based molecular imaging agents. This work focuses on the development of a standardized platform to facilitate the reliable and efficient synthesis of high-purity fluorine-18 radiolabeled peptides for in vivo imaging with positron emission tomography (PET). Seven commercially available resins were selected for solid-phase radiolabeling of the model peptide VQAAIDYING with 4-[18F]fluorobenzoic acid ([18F]FBA). A wide range of radiochemical yields (18.8±1.5% to 41.2±5.3%) was obtained using standard conditions (coupling: 3 eq amino acid, 3 eq HATU, 6 eq DIPEA, 1.5 h, r.t.; cleavage: 94% TFA, 3 h, r.t.). After modification of coupling reagents and employing heated reactions to 37 °C, radiochemical yields were improved by as much as 35.3% over standard conditions. When the optimized conditions were applied to the synthesis of [18F]FBA-PEG28-A20FMDV2, which targets the αvβ6 integrin in vivo, radiochemical yields improved by as much as 73.4% over those obtained using standard coupling and cleavage conditions. This platform can be utilized to improve the synthesis of peptide-based molecular probes for molecular imaging with PET." @default.
- W2080454950 created "2016-06-24" @default.
- W2080454950 creator A5018129304 @default.
- W2080454950 creator A5026077321 @default.
- W2080454950 creator A5037395136 @default.
- W2080454950 creator A5050421121 @default.
- W2080454950 date "2012-12-01" @default.
- W2080454950 modified "2023-10-14" @default.
- W2080454950 title "Optimization of the solid-phase synthesis of [18F] radiolabeled peptides for positron emission tomography" @default.
- W2080454950 cites W1596343500 @default.
- W2080454950 cites W1861064994 @default.
- W2080454950 cites W1928915926 @default.
- W2080454950 cites W1972856344 @default.
- W2080454950 cites W1973249565 @default.
- W2080454950 cites W1987049315 @default.
- W2080454950 cites W1989227696 @default.
- W2080454950 cites W1991703770 @default.
- W2080454950 cites W1996329525 @default.
- W2080454950 cites W1998236525 @default.
- W2080454950 cites W2010457012 @default.
- W2080454950 cites W2012407162 @default.
- W2080454950 cites W2031147501 @default.
- W2080454950 cites W2034730058 @default.
- W2080454950 cites W2036371444 @default.
- W2080454950 cites W2044297017 @default.
- W2080454950 cites W2051074466 @default.
- W2080454950 cites W2052309624 @default.
- W2080454950 cites W2052722985 @default.
- W2080454950 cites W2055877006 @default.
- W2080454950 cites W2057064048 @default.
- W2080454950 cites W2058027992 @default.
- W2080454950 cites W2060340988 @default.
- W2080454950 cites W2071168359 @default.
- W2080454950 cites W2072907221 @default.
- W2080454950 cites W2078071703 @default.
- W2080454950 cites W2081915343 @default.
- W2080454950 cites W2084413748 @default.
- W2080454950 cites W2084776720 @default.
- W2080454950 cites W2085054929 @default.
- W2080454950 cites W2103886595 @default.
- W2080454950 cites W2106714479 @default.
- W2080454950 cites W2107303896 @default.
- W2080454950 cites W2115470717 @default.
- W2080454950 cites W2131119538 @default.
- W2080454950 cites W2151749346 @default.
- W2080454950 cites W2171980738 @default.
- W2080454950 cites W2313482997 @default.
- W2080454950 cites W2320556745 @default.
- W2080454950 cites W2324519667 @default.
- W2080454950 doi "https://doi.org/10.1016/j.apradiso.2012.08.003" @default.
- W2080454950 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23041391" @default.
- W2080454950 hasPublicationYear "2012" @default.
- W2080454950 type Work @default.
- W2080454950 sameAs 2080454950 @default.
- W2080454950 citedByCount "8" @default.
- W2080454950 countsByYear W20804549502013 @default.
- W2080454950 countsByYear W20804549502014 @default.
- W2080454950 countsByYear W20804549502019 @default.
- W2080454950 countsByYear W20804549502020 @default.
- W2080454950 countsByYear W20804549502021 @default.
- W2080454950 crossrefType "journal-article" @default.
- W2080454950 hasAuthorship W2080454950A5018129304 @default.
- W2080454950 hasAuthorship W2080454950A5026077321 @default.
- W2080454950 hasAuthorship W2080454950A5037395136 @default.
- W2080454950 hasAuthorship W2080454950A5050421121 @default.
- W2080454950 hasConcept C136339569 @default.
- W2080454950 hasConcept C150903083 @default.
- W2080454950 hasConcept C177322064 @default.
- W2080454950 hasConcept C178790620 @default.
- W2080454950 hasConcept C185592680 @default.
- W2080454950 hasConcept C207001950 @default.
- W2080454950 hasConcept C21951064 @default.
- W2080454950 hasConcept C2775842073 @default.
- W2080454950 hasConcept C2776469878 @default.
- W2080454950 hasConcept C2779281246 @default.
- W2080454950 hasConcept C2779809887 @default.
- W2080454950 hasConcept C2989005 @default.
- W2080454950 hasConcept C40875361 @default.
- W2080454950 hasConcept C515207424 @default.
- W2080454950 hasConcept C55493867 @default.
- W2080454950 hasConcept C71924100 @default.
- W2080454950 hasConcept C86803240 @default.
- W2080454950 hasConceptScore W2080454950C136339569 @default.
- W2080454950 hasConceptScore W2080454950C150903083 @default.
- W2080454950 hasConceptScore W2080454950C177322064 @default.
- W2080454950 hasConceptScore W2080454950C178790620 @default.
- W2080454950 hasConceptScore W2080454950C185592680 @default.
- W2080454950 hasConceptScore W2080454950C207001950 @default.
- W2080454950 hasConceptScore W2080454950C21951064 @default.
- W2080454950 hasConceptScore W2080454950C2775842073 @default.
- W2080454950 hasConceptScore W2080454950C2776469878 @default.
- W2080454950 hasConceptScore W2080454950C2779281246 @default.
- W2080454950 hasConceptScore W2080454950C2779809887 @default.
- W2080454950 hasConceptScore W2080454950C2989005 @default.
- W2080454950 hasConceptScore W2080454950C40875361 @default.
- W2080454950 hasConceptScore W2080454950C515207424 @default.
- W2080454950 hasConceptScore W2080454950C55493867 @default.
- W2080454950 hasConceptScore W2080454950C71924100 @default.