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- W2080455101 abstract "Mesoderm of axolotl embryos at various developmental stages was briefly exposed to a calcium-free 0.01% trypsin solution by temporary removal of the epidermis. This treatment was found to disrupt somite segmentation in a localized region and the pronephric duct was unable to migrate through this region. The affected area, consisting of 3.91 ± 1.04 somites, traveled through the embryo in synchrony with, and 3.55 ± 0.69-somite widths ahead of segmentation. Trypsinization in the presence of 340 μM calcium resulted in normal duct migration while somite segmentation was still affected. These results demonstrate the existence of a trypsin-sensitive region in the somitic mesoderm and the lateral mesoderm of the duct path that travels in advance of somite segmentation and in synchrony with it. In addition, the trypsin sensitivity of the duct path is calcium dependent whereas that of the somitic mesoderm is not." @default.
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- W2080455101 date "1985-01-01" @default.
- W2080455101 modified "2023-10-18" @default.
- W2080455101 title "Experimental evidence for a proteinaceous presegmental wave required for morphogenesis of axolotl mesoderm" @default.
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- W2080455101 doi "https://doi.org/10.1016/0012-1606(85)90390-2" @default.
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