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- W2080456521 abstract "Bioactivity-directed fractionation of the organic extracts of two filamentous fungi of the Bionectriaceae, strains MSX 64546 and MSX 59553 from the Mycosynthetix library, led to the isolation of a new dimeric epipolythiodioxopiperazine alkaloid, verticillin H (1), along with six related analogs, Sch 52900 (2), verticillin A (3), gliocladicillin C (4), Sch 52901 (5), 11′-deoxyverticillin A (6) and gliocladicillin A (7). The structures of compounds 1 – 7 were determined by extensive NMR and HRMS analyses, as well as by comparisons to the literature. All compounds (1 – 7) were evaluated for cytotoxicity against a panel of human cancer cell lines, displaying IC50 values ranging from 1.2 μM to 10 nM. Compounds 1 – 5 were examined for activity in the NF-κB assay, where compounds 2 and 3 revealed activity in the sub-micromolar range. Additionally, compounds 1, 3 and 4 were tested for EGFR inhibition using an enzymatic assay, while compound 3 was examined against an overexpressing EGFR+ve cancer cell line." @default.
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- W2080456521 date "2012-09-12" @default.
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- W2080456521 title "Cytotoxic epipolythiodioxopiperazine alkaloids from filamentous fungi of the Bionectriaceae" @default.
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- W2080456521 doi "https://doi.org/10.1038/ja.2012.69" @default.
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