FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2080456946> ?p ?o ?g. }

• W2080456946 endingPage "9591" @default.
• W2080456946 startingPage "9586" @default.
• W2080456946 abstract "In this study, collagen extracted from chicken legs (which are the yellow keratin parts containing a nail) was hydrolyzed with various enzymes, and the angiotensin I-converting enzyme (ACE)-inhibitory activity of each hydrolysate was determined. The hydrolysate by treatment with an Aspergillus species-derived enzyme had the highest activity (IC 50 = 260 microg/mL). The fraction of this hydrolysate obtained by ultrafiltration with a molecular-weight cutoff of 3000 Da (low fraction) had a stronger activity (IC 50 = 130 microg/mL) than the fractionated one. This fraction was further fractionated by HPLC, and the peptides in the fraction with high ACE-inhibitory activity were identified. The amino acid sequences of the four peptides were identified using a protein sequencer. These peptides were synthesized to confirm their ACE-inhibitory activities; this showed that peptides with a Gly-Ala-Hyp-Gly-Leu-Hyp-Gly-Pro sequence had the highest activity (IC 50 = 29 microM). When the low fraction was administered to spontaneous hypertensive rats, a decrease in their blood pressure was observed after 2 h of administration, and a significant decrease in blood pressure (-50 mmHg) was observed after 6 h. Moreover, long-term administration studies indicated that the low fraction showed a significant suppression of increased blood pressure." @default.
• W2080456946 created "2016-06-24" @default.
• W2080456946 creator A5030456470 @default.
• W2080456946 creator A5033393526 @default.
• W2080456946 creator A5040435627 @default.
• W2080456946 creator A5047256984 @default.
• W2080456946 creator A5047704737 @default.
• W2080456946 creator A5075506418 @default.
• W2080456946 creator A5081810349 @default.
• W2080456946 date "2008-09-23" @default.
• W2080456946 modified "2023-10-18" @default.
• W2080456946 title "Angiotensin I-Converting Enzyme-Inhibitory Peptides Obtained from Chicken Collagen Hydrolysate" @default.
• W2080456946 cites W1611092567 @default.
• W2080456946 cites W1963841287 @default.
• W2080456946 cites W1978389916 @default.
• W2080456946 cites W1988513455 @default.
• W2080456946 cites W1991329098 @default.
• W2080456946 cites W1992009169 @default.
• W2080456946 cites W2040170936 @default.
• W2080456946 cites W2052418725 @default.
• W2080456946 cites W2054847197 @default.
• W2080456946 cites W2067492256 @default.
• W2080456946 cites W2073110854 @default.
• W2080456946 cites W2074665772 @default.
• W2080456946 cites W2076521545 @default.
• W2080456946 cites W2081328049 @default.
• W2080456946 cites W2083671868 @default.
• W2080456946 cites W2087447071 @default.
• W2080456946 cites W2116717490 @default.
• W2080456946 cites W2144425327 @default.
• W2080456946 cites W2164723689 @default.
• W2080456946 doi "https://doi.org/10.1021/jf072669w" @default.
• W2080456946 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18808143" @default.
• W2080456946 hasPublicationYear "2008" @default.
• W2080456946 type Work @default.
• W2080456946 sameAs 2080456946 @default.
• W2080456946 citedByCount "156" @default.
• W2080456946 countsByYear W20804569462012 @default.
• W2080456946 countsByYear W20804569462013 @default.
• W2080456946 countsByYear W20804569462014 @default.
• W2080456946 countsByYear W20804569462015 @default.
• W2080456946 countsByYear W20804569462016 @default.
• W2080456946 countsByYear W20804569462017 @default.
• W2080456946 countsByYear W20804569462018 @default.
• W2080456946 countsByYear W20804569462019 @default.
• W2080456946 countsByYear W20804569462020 @default.
• W2080456946 countsByYear W20804569462021 @default.
• W2080456946 countsByYear W20804569462022 @default.
• W2080456946 countsByYear W20804569462023 @default.
• W2080456946 crossrefType "journal-article" @default.
• W2080456946 hasAuthorship W2080456946A5030456470 @default.
• W2080456946 hasAuthorship W2080456946A5033393526 @default.
• W2080456946 hasAuthorship W2080456946A5040435627 @default.
• W2080456946 hasAuthorship W2080456946A5047256984 @default.
• W2080456946 hasAuthorship W2080456946A5047704737 @default.
• W2080456946 hasAuthorship W2080456946A5075506418 @default.
• W2080456946 hasAuthorship W2080456946A5081810349 @default.
• W2080456946 hasBestOaLocation W20804569461 @default.
• W2080456946 hasConcept C134018914 @default.
• W2080456946 hasConcept C181199279 @default.
• W2080456946 hasConcept C185592680 @default.
• W2080456946 hasConcept C198710026 @default.
• W2080456946 hasConcept C27016395 @default.
• W2080456946 hasConcept C2779281246 @default.
• W2080456946 hasConcept C28212737 @default.
• W2080456946 hasConcept C28800991 @default.
• W2080456946 hasConcept C43617362 @default.
• W2080456946 hasConcept C50817676 @default.
• W2080456946 hasConcept C55493867 @default.
• W2080456946 hasConcept C84393581 @default.
• W2080456946 hasConcept C86803240 @default.
• W2080456946 hasConcept C94412978 @default.
• W2080456946 hasConcept C98274493 @default.
• W2080456946 hasConceptScore W2080456946C134018914 @default.
• W2080456946 hasConceptScore W2080456946C181199279 @default.
• W2080456946 hasConceptScore W2080456946C185592680 @default.
• W2080456946 hasConceptScore W2080456946C198710026 @default.
• W2080456946 hasConceptScore W2080456946C27016395 @default.
• W2080456946 hasConceptScore W2080456946C2779281246 @default.
• W2080456946 hasConceptScore W2080456946C28212737 @default.
• W2080456946 hasConceptScore W2080456946C28800991 @default.
• W2080456946 hasConceptScore W2080456946C43617362 @default.
• W2080456946 hasConceptScore W2080456946C50817676 @default.
• W2080456946 hasConceptScore W2080456946C55493867 @default.
• W2080456946 hasConceptScore W2080456946C84393581 @default.
• W2080456946 hasConceptScore W2080456946C86803240 @default.
• W2080456946 hasConceptScore W2080456946C94412978 @default.
• W2080456946 hasConceptScore W2080456946C98274493 @default.
• W2080456946 hasIssue "20" @default.
• W2080456946 hasLocation W20804569461 @default.
• W2080456946 hasLocation W20804569462 @default.
• W2080456946 hasOpenAccess W2080456946 @default.
• W2080456946 hasPrimaryLocation W20804569461 @default.
• W2080456946 hasRelatedWork W2011705357 @default.
• W2080456946 hasRelatedWork W2039453680 @default.
• W2080456946 hasRelatedWork W2040608383 @default.
• W2080456946 hasRelatedWork W2059333130 @default.
• W2080456946 hasRelatedWork W2288306500 @default.

• next