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• W2080459009 abstract "It is now well established - based on longitudinal brain MRI - that MCI and AD are each associated with higher rates of brain atrophy compared to normal aging, involving especially the hippocampus. New data further suggests that higher atrophy rates are also associated with the ApoE allele e4 gene (ApoE4) and low cerebrospinal fluid beta-amyloid (CSF Ab1-42). Therefore, an interesting question arises whether ApoE4 and low CSF- Ab1-42 are separately or together associated with higher rates of brain atrophy. In addition to low CSF- Ab1-42, elevated CSF phosphorylated tau (p-tau181p) may also be associated with brain atrophy. However, CSF biomarkers lack information about the distribution of pathology in the brain. In this presentation, new findings of relationships among ApoE, CSF Ab1-42, CSF p-tau181p and MRI measures of increased brain atrophy are reviewed. The analysis is based on ADNI data from a large number of subjects, who had longitudinal MRI scans, lumbar punctuation at baseline, and genetic tests. Changes in brain volumes and cortical thickness were measured using automated image processing software. CSF Ab1-42, CSF p-tau181p and the ApoE profile were determined using standard methods. The effects of CSF biomarkers and ApoE4 on structural brain changes were tested using generalized linear mixed effect models, supplemented by maximum likelihood tests to determine the extent to which each factor contributes to variations in the brain. Increased atrophy rates of hippocampus were associated with the ApoE4 allele in AD and lower CSF Ab1-42 in MCI, whereas relations with CSF p-tau181p were only trends. Moreover, increased atrophy rates of hippocampus were associates with a significant interaction between ApoE4 and CSF Aβ in MCI and AD. Finally, lower baseline CSF Ab1-42 and higher p-tau181p were generally associated with higher rates of regional cortical thinning, involving primarily the temporoparietal cortex. These effects were most prominent in MCI subjects. The results suggest ApoE4 effects on amyloid-mediated brain atrophy are stage- specific. Furthermore, amyloid- and tau-mediated brain atrophy is regionally variable. Taken together, the information has uses for early detection of AD and evaluation of treatment interventions." @default.
• W2080459009 created "2016-06-24" @default.
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• W2080459009 date "2010-07-01" @default.
• W2080459009 modified "2023-09-27" @default.
• W2080459009 title "S3-03-04: MRI of brain atrophy in early Alzheimer's disease in relation to ApoE genotype and biomarkers" @default.
• W2080459009 doi "https://doi.org/10.1016/j.jalz.2010.05.385" @default.
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