Matches in SemOpenAlex for { <https://semopenalex.org/work/W2080469937> ?p ?o ?g. }
- W2080469937 endingPage "10918" @default.
- W2080469937 startingPage "10903" @default.
- W2080469937 abstract "The sense of hearing depends on the faithful transmission of sound information from the ear to the brain by spiral ganglion (SG) neurons. However, how SG neurons develop the connections and properties that underlie auditory processing is largely unknown. We catalogued gene expression in mouse SG neurons from embryonic day 12, when SG neurons first extend projections, up until postnatal day 15, after the onset of hearing. For comparison, we also analyzed the closely related vestibular ganglion (VG). Gene ontology analysis confirmed enriched expression of genes associated with gene regulation and neurite outgrowth at early stages, with the SG and VG often expressing different members of the same gene family. At later stages, the neurons transcribe more genes related to mature function, and exhibit a dramatic increase in immune gene expression. Comparisons of the two populations revealed enhanced expression of TGFβ pathway components in SG neurons and established new markers that consistently distinguish auditory and vestibular neurons. Unexpectedly, we found that Gata3, a transcription factor commonly associated with auditory development, is also expressed in VG neurons at early stages. We therefore defined new cohorts of transcription factors and axon guidance molecules that are uniquely expressed in SG neurons and may drive auditory-specific aspects of their differentiation and wiring. We show that one of these molecules, the receptor guanylyl cyclase Npr2, is required for bifurcation of the SG central axon. Hence, our dataset provides a useful resource for uncovering the molecular basis of specific auditory circuit assembly events." @default.
- W2080469937 created "2016-06-24" @default.
- W2080469937 creator A5019953238 @default.
- W2080469937 creator A5020135419 @default.
- W2080469937 creator A5037526460 @default.
- W2080469937 creator A5038687910 @default.
- W2080469937 date "2011-07-27" @default.
- W2080469937 modified "2023-10-14" @default.
- W2080469937 title "Developmental Profiling of Spiral Ganglion Neurons Reveals Insights into Auditory Circuit Assembly" @default.
- W2080469937 cites W1496964709 @default.
- W2080469937 cites W153435493 @default.
- W2080469937 cites W1538641465 @default.
- W2080469937 cites W1768274470 @default.
- W2080469937 cites W1966338613 @default.
- W2080469937 cites W1966987832 @default.
- W2080469937 cites W1971359363 @default.
- W2080469937 cites W1972167096 @default.
- W2080469937 cites W1974594271 @default.
- W2080469937 cites W1974813892 @default.
- W2080469937 cites W1974840646 @default.
- W2080469937 cites W1977290012 @default.
- W2080469937 cites W1979749961 @default.
- W2080469937 cites W1980481550 @default.
- W2080469937 cites W1986463751 @default.
- W2080469937 cites W1990545433 @default.
- W2080469937 cites W1990991867 @default.
- W2080469937 cites W1995506998 @default.
- W2080469937 cites W1996273748 @default.
- W2080469937 cites W1999747077 @default.
- W2080469937 cites W2013348327 @default.
- W2080469937 cites W2016041998 @default.
- W2080469937 cites W2017400430 @default.
- W2080469937 cites W2018738048 @default.
- W2080469937 cites W2019859503 @default.
- W2080469937 cites W2021314608 @default.
- W2080469937 cites W2026034241 @default.
- W2080469937 cites W2028665355 @default.
- W2080469937 cites W2032284140 @default.
- W2080469937 cites W2033403400 @default.
- W2080469937 cites W2035022202 @default.
- W2080469937 cites W2043273933 @default.
- W2080469937 cites W2047249162 @default.
- W2080469937 cites W2063965661 @default.
- W2080469937 cites W2069577821 @default.
- W2080469937 cites W2070074690 @default.
- W2080469937 cites W2071641360 @default.
- W2080469937 cites W2076088789 @default.
- W2080469937 cites W2077862137 @default.
- W2080469937 cites W2081854672 @default.
- W2080469937 cites W2085830550 @default.
- W2080469937 cites W2086536594 @default.
- W2080469937 cites W2088483102 @default.
- W2080469937 cites W2089819518 @default.
- W2080469937 cites W2090442905 @default.
- W2080469937 cites W2090639766 @default.
- W2080469937 cites W2092996761 @default.
- W2080469937 cites W2096327192 @default.
- W2080469937 cites W2096599909 @default.
- W2080469937 cites W2096715243 @default.
- W2080469937 cites W2103370854 @default.
- W2080469937 cites W2110340803 @default.
- W2080469937 cites W2118492208 @default.
- W2080469937 cites W2124940469 @default.
- W2080469937 cites W2131583554 @default.
- W2080469937 cites W2132719151 @default.
- W2080469937 cites W2138072363 @default.
- W2080469937 cites W2143076872 @default.
- W2080469937 cites W2145577225 @default.
- W2080469937 cites W2148076103 @default.
- W2080469937 cites W2148908926 @default.
- W2080469937 cites W2149680840 @default.
- W2080469937 cites W2152471910 @default.
- W2080469937 cites W2155899899 @default.
- W2080469937 cites W2160262432 @default.
- W2080469937 cites W2161803347 @default.
- W2080469937 cites W2161851299 @default.
- W2080469937 cites W2164045258 @default.
- W2080469937 cites W2164256038 @default.
- W2080469937 cites W1966500087 @default.
- W2080469937 doi "https://doi.org/10.1523/jneurosci.2358-11.2011" @default.
- W2080469937 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3167573" @default.
- W2080469937 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21795542" @default.
- W2080469937 hasPublicationYear "2011" @default.
- W2080469937 type Work @default.
- W2080469937 sameAs 2080469937 @default.
- W2080469937 citedByCount "126" @default.
- W2080469937 countsByYear W20804699372012 @default.
- W2080469937 countsByYear W20804699372013 @default.
- W2080469937 countsByYear W20804699372014 @default.
- W2080469937 countsByYear W20804699372015 @default.
- W2080469937 countsByYear W20804699372016 @default.
- W2080469937 countsByYear W20804699372017 @default.
- W2080469937 countsByYear W20804699372018 @default.
- W2080469937 countsByYear W20804699372019 @default.
- W2080469937 countsByYear W20804699372020 @default.
- W2080469937 countsByYear W20804699372021 @default.
- W2080469937 countsByYear W20804699372022 @default.
- W2080469937 countsByYear W20804699372023 @default.