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- W2080471574 abstract "The inhibitory postseizure effect of electroconvulsive shock (ECS) and of kindled seizures on kindled seizures was assessed. Rats were kindled by daily amygdaloid stimulation. ECS delivered 22 or 24 h before each kindling stimulus markedly reduced the rate of kindling. In fully kindled rats multiple but not single ECS raised the threshold to kindled seizures 24 and 48 h after the last ECS. The threshold returned to normal after a rest period. In a subsequent experiment the threshold of fully kindled seizures was measured once daily for 8 consecutive days. The threshold was found to increase to a plateau, then return to normal after a 15-day rest. Multiple seizures are more effective than single seizures in inducing the postseizure effect; the phenomenon is not seizure specific. It is postulated that multiple seizures induce a homeostatic inhibiting response." @default.
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- W2080471574 date "1982-12-01" @default.
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- W2080471574 title "Postseizure inhibition of kindled seizures by electroconvulsive shock" @default.
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- W2080471574 doi "https://doi.org/10.1016/0014-4886(82)90068-1" @default.
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