FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2080472139> ?p ?o ?g. }

• W2080472139 endingPage "9256" @default.
• W2080472139 startingPage "9247" @default.
• W2080472139 abstract "A neural glycotope, human natural killer-1 carbohydrate, is involved in synaptic plasticity. The key biosynthetic enzyme is a glucuronyltransferase, GlcAT-P, a type II membrane protein comprising an N-terminal cytoplasmic tail, transmembrane domain, stem region, and C-terminal catalytic domain. Previously, we reported that GlcAT-P has two isoforms differing in only the presence or absence of the N-terminal 13 amino acids (P-N13) in the cytoplasmic tail, but the functional distinction of these two isoforms has not been reported. Herein, we show that when expressed in Neuro2A cells, short form GlcAT-P (sGlcAT-P) exhibited significantly higher glucuronylation activity than the longer form (lGlcAT-P), despite their comparable specific activities in vitro. In addition, sGlcAT-P was strictly localized in Golgi apparatus, whereas lGlcAT-P was mainly localized in Golgi but partly in the endoplasmic reticulum. We demonstrated that the small GTPase, Sar1, recognized a dibasic motif in the cytoplasmic tail near P-N13 that was important for exiting the endoplasmic reticulum, and Sar1 interacted with sGlcAT-P more strongly than lGlcAT-P. Finally, the attachment of P-N13 to another glycosyltransferase, polysialyltransferase-I (ST8Sia-IV), had similar effects, such as reduced activity and entrapment within endoplasmic reticulum. These results suggest that P-N13 can control glycosyltransferase transport through Sar1 binding interference." @default.
• W2080472139 created "2016-06-24" @default.
• W2080472139 creator A5019847915 @default.
• W2080472139 creator A5059002532 @default.
• W2080472139 creator A5088212118 @default.
• W2080472139 date "2009-04-01" @default.
• W2080472139 modified "2023-10-16" @default.
• W2080472139 title "Distinct Transport and Intracellular Activities of Two GlcAT-P Isoforms" @default.
• W2080472139 cites W1490131901 @default.
• W2080472139 cites W1498848540 @default.
• W2080472139 cites W1500163587 @default.
• W2080472139 cites W1964709514 @default.
• W2080472139 cites W1977023268 @default.
• W2080472139 cites W1986616082 @default.
• W2080472139 cites W1989893248 @default.
• W2080472139 cites W1994545190 @default.
• W2080472139 cites W1996248759 @default.
• W2080472139 cites W1996339481 @default.
• W2080472139 cites W2003552716 @default.
• W2080472139 cites W2003998454 @default.
• W2080472139 cites W2005119441 @default.
• W2080472139 cites W2007100262 @default.
• W2080472139 cites W2008833078 @default.
• W2080472139 cites W2024191848 @default.
• W2080472139 cites W2035248852 @default.
• W2080472139 cites W2037083628 @default.
• W2080472139 cites W2052992979 @default.
• W2080472139 cites W2057680379 @default.
• W2080472139 cites W2065984759 @default.
• W2080472139 cites W2074632380 @default.
• W2080472139 cites W2083273192 @default.
• W2080472139 cites W2092335738 @default.
• W2080472139 cites W2098145494 @default.
• W2080472139 cites W2099986642 @default.
• W2080472139 cites W2104089191 @default.
• W2080472139 cites W2105955533 @default.
• W2080472139 cites W2130452852 @default.
• W2080472139 cites W2131756548 @default.
• W2080472139 cites W2144797900 @default.
• W2080472139 cites W2146165616 @default.
• W2080472139 cites W2153491115 @default.
• W2080472139 cites W2153903656 @default.
• W2080472139 cites W2167064657 @default.
• W2080472139 cites W2167558046 @default.
• W2080472139 doi "https://doi.org/10.1074/jbc.m807517200" @default.
• W2080472139 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2666577" @default.
• W2080472139 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19181664" @default.
• W2080472139 hasPublicationYear "2009" @default.
• W2080472139 type Work @default.
• W2080472139 sameAs 2080472139 @default.
• W2080472139 citedByCount "18" @default.
• W2080472139 countsByYear W20804721392012 @default.
• W2080472139 countsByYear W20804721392013 @default.
• W2080472139 countsByYear W20804721392014 @default.
• W2080472139 countsByYear W20804721392015 @default.
• W2080472139 countsByYear W20804721392016 @default.
• W2080472139 countsByYear W20804721392017 @default.
• W2080472139 countsByYear W20804721392018 @default.
• W2080472139 countsByYear W20804721392020 @default.
• W2080472139 countsByYear W20804721392021 @default.
• W2080472139 countsByYear W20804721392022 @default.
• W2080472139 crossrefType "journal-article" @default.
• W2080472139 hasAuthorship W2080472139A5019847915 @default.
• W2080472139 hasAuthorship W2080472139A5059002532 @default.
• W2080472139 hasAuthorship W2080472139A5088212118 @default.
• W2080472139 hasBestOaLocation W20804721391 @default.
• W2080472139 hasConcept C104317684 @default.
• W2080472139 hasConcept C118892022 @default.
• W2080472139 hasConcept C119062480 @default.
• W2080472139 hasConcept C158617107 @default.
• W2080472139 hasConcept C170493617 @default.
• W2080472139 hasConcept C185592680 @default.
• W2080472139 hasConcept C190062978 @default.
• W2080472139 hasConcept C24530287 @default.
• W2080472139 hasConcept C515207424 @default.
• W2080472139 hasConcept C53345823 @default.
• W2080472139 hasConcept C55493867 @default.
• W2080472139 hasConcept C79879829 @default.
• W2080472139 hasConcept C86803240 @default.
• W2080472139 hasConcept C95444343 @default.
• W2080472139 hasConceptScore W2080472139C104317684 @default.
• W2080472139 hasConceptScore W2080472139C118892022 @default.
• W2080472139 hasConceptScore W2080472139C119062480 @default.
• W2080472139 hasConceptScore W2080472139C158617107 @default.
• W2080472139 hasConceptScore W2080472139C170493617 @default.
• W2080472139 hasConceptScore W2080472139C185592680 @default.
• W2080472139 hasConceptScore W2080472139C190062978 @default.
• W2080472139 hasConceptScore W2080472139C24530287 @default.
• W2080472139 hasConceptScore W2080472139C515207424 @default.
• W2080472139 hasConceptScore W2080472139C53345823 @default.
• W2080472139 hasConceptScore W2080472139C55493867 @default.
• W2080472139 hasConceptScore W2080472139C79879829 @default.
• W2080472139 hasConceptScore W2080472139C86803240 @default.
• W2080472139 hasConceptScore W2080472139C95444343 @default.
• W2080472139 hasIssue "14" @default.
• W2080472139 hasLocation W20804721391 @default.
• W2080472139 hasLocation W20804721392 @default.
• W2080472139 hasLocation W20804721393 @default.

• next