FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2080472404> ?p ?o ?g. }

• W2080472404 endingPage "373" @default.
• W2080472404 startingPage "365" @default.
• W2080472404 abstract "Chronic constipation (CC) is a common problem worldwide and, for some sufferers, a cause of considerable morbidity. Recent definitions of CC have moved from the former emphasis on stool frequency alone to a broader concept that strives to encompass the various symptoms that may bother afflicted individuals. Accordingly, new therapies attempt to not only increase frequency of defecation but also to address such symptoms as satisfaction with bowel action, straining, bloating, and distension.To provide context the relative merits and problems related to conventional laxative-based approaches to constipation are first reviewed and then more recent novel pharmacological approaches to the management of constipation assessed. The focus is on two classes of compounds, selective prokinetics and prosecretory agents, and studies on their efficacy and safety in chronic idiopathic constipation were retrieved and evaluated.While undoubtedly effective, high-quality evidence to support laxatives, the traditional remedies for constipation, is remarkably scarce due, in large part, to the absence, until very recently, of high-quality randomized controlled clinical trials. The selective prokinetic agent prucalopride and the prosecretory agents lubiprostone and linaclotide have shown efficacy and been associated with a good safety record in large well-conducted clinical studies. Other novel approaches, such as the inhibition of ileal bile salt absorption, offer particular promise." @default.
• W2080472404 created "2016-06-24" @default.
• W2080472404 creator A5038102817 @default.
• W2080472404 creator A5057942505 @default.
• W2080472404 date "2013-08-20" @default.
• W2080472404 modified "2023-09-27" @default.
• W2080472404 title "Emerging treatments for chronic constipation" @default.
• W2080472404 cites W1482604334 @default.
• W2080472404 cites W1486462492 @default.
• W2080472404 cites W1570135279 @default.
• W2080472404 cites W1604467628 @default.
• W2080472404 cites W1826937932 @default.
• W2080472404 cites W1860428680 @default.
• W2080472404 cites W1921373566 @default.
• W2080472404 cites W1965194352 @default.
• W2080472404 cites W1968228152 @default.
• W2080472404 cites W1971440285 @default.
• W2080472404 cites W1973959910 @default.
• W2080472404 cites W1987172422 @default.
• W2080472404 cites W1988920656 @default.
• W2080472404 cites W1995092048 @default.
• W2080472404 cites W1995144812 @default.
• W2080472404 cites W1995161897 @default.
• W2080472404 cites W1997800332 @default.
• W2080472404 cites W1998332693 @default.
• W2080472404 cites W2001830981 @default.
• W2080472404 cites W2003147380 @default.
• W2080472404 cites W2005068072 @default.
• W2080472404 cites W2011319006 @default.
• W2080472404 cites W2018961807 @default.
• W2080472404 cites W2021600448 @default.
• W2080472404 cites W2028610080 @default.
• W2080472404 cites W2031129058 @default.
• W2080472404 cites W2033115639 @default.
• W2080472404 cites W2039342085 @default.
• W2080472404 cites W2041581988 @default.
• W2080472404 cites W2042615016 @default.
• W2080472404 cites W2050769859 @default.
• W2080472404 cites W2061044370 @default.
• W2080472404 cites W2064201279 @default.
• W2080472404 cites W2068454300 @default.
• W2080472404 cites W2075335843 @default.
• W2080472404 cites W2076235879 @default.
• W2080472404 cites W2079448135 @default.
• W2080472404 cites W2080887170 @default.
• W2080472404 cites W2085025198 @default.
• W2080472404 cites W2088698613 @default.
• W2080472404 cites W2089084311 @default.
• W2080472404 cites W2099768372 @default.
• W2080472404 cites W2105499052 @default.
• W2080472404 cites W2123111797 @default.
• W2080472404 cites W2129385409 @default.
• W2080472404 cites W2132145612 @default.
• W2080472404 cites W2135918186 @default.
• W2080472404 cites W2138857851 @default.
• W2080472404 cites W2149135442 @default.
• W2080472404 cites W2154965232 @default.
• W2080472404 cites W2165844124 @default.
• W2080472404 cites W2167159877 @default.
• W2080472404 cites W2168967776 @default.
• W2080472404 cites W2601791777 @default.
• W2080472404 cites W60453086 @default.
• W2080472404 doi "https://doi.org/10.1517/14728214.2013.831068" @default.
• W2080472404 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23957819" @default.
• W2080472404 hasPublicationYear "2013" @default.
• W2080472404 type Work @default.
• W2080472404 sameAs 2080472404 @default.
• W2080472404 citedByCount "9" @default.
• W2080472404 countsByYear W20804724042014 @default.
• W2080472404 countsByYear W20804724042015 @default.
• W2080472404 countsByYear W20804724042016 @default.
• W2080472404 countsByYear W20804724042017 @default.
• W2080472404 countsByYear W20804724042022 @default.
• W2080472404 crossrefType "journal-article" @default.
• W2080472404 hasAuthorship W2080472404A5038102817 @default.
• W2080472404 hasAuthorship W2080472404A5057942505 @default.
• W2080472404 hasConcept C126322002 @default.
• W2080472404 hasConcept C151730666 @default.
• W2080472404 hasConcept C168563851 @default.
• W2080472404 hasConcept C177713679 @default.
• W2080472404 hasConcept C2776956441 @default.
• W2080472404 hasConcept C2778271842 @default.
• W2080472404 hasConcept C2779343474 @default.
• W2080472404 hasConcept C2780580376 @default.
• W2080472404 hasConcept C2780661987 @default.
• W2080472404 hasConcept C2781093762 @default.
• W2080472404 hasConcept C2781112942 @default.
• W2080472404 hasConcept C3017955636 @default.
• W2080472404 hasConcept C535046627 @default.
• W2080472404 hasConcept C71924100 @default.
• W2080472404 hasConcept C86803240 @default.
• W2080472404 hasConceptScore W2080472404C126322002 @default.
• W2080472404 hasConceptScore W2080472404C151730666 @default.
• W2080472404 hasConceptScore W2080472404C168563851 @default.
• W2080472404 hasConceptScore W2080472404C177713679 @default.
• W2080472404 hasConceptScore W2080472404C2776956441 @default.
• W2080472404 hasConceptScore W2080472404C2778271842 @default.
• W2080472404 hasConceptScore W2080472404C2779343474 @default.

• next