FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2080474955> ?p ?o ?g. }

• W2080474955 endingPage "1238" @default.
• W2080474955 startingPage "1226" @default.
• W2080474955 abstract "Consistent sex differences in regulation of the hypothalamic pituitary adrenocortical (HPA) axis have been shown in animal models and emerge over puberty. However, parallel work in humans is lacking despite implications for elucidating the emergence of sex differences in depression over puberty. We investigated sex differences in HPA response to corticotropin releasing hormone (CRH) challenge over puberty in a carefully screened normative sample.Participants were 68 healthy children (41% girls), ages 6-16, with no personal or family history of psychiatric disorder. Pubertal maturation was determined by Tanner staging. Following 24h of adaptation, 9-10 plasma cortisol samples were collected over 30-40 min pre-infusion baseline, 1 μg/kg CRH infusion, and 90-180 min post-infusion recovery. Thirty-seven participants completed 2+ CRH challenges allowing inclusion of cross-sectional and longitudinal data in all analyses. The influence of gender and pubertal maturation on parameters of cortisol response to CRH challenge was investigated using nonlinear mixed model methodology.Girls showed increasing total cortisol output following CRH challenge over puberty, while boys showed little change in total cortisol output over puberty. Increased cortisol output in girls was explained by slower reactivity and recovery rates leading to prolonged time to reach peak cortisol and delayed return to baseline over puberty. Girls also showed increasing baseline cortisol over puberty, while boys showed declining baseline over puberty.Results reveal subtle normative sex differences in the influence of pubertal maturation on HPA regulation at the pituitary level. This normative shift may tip the balance towards stress response dysregulation in girls at high risk for depression, and may represent one potential mechanism underlying elevated rates of depression among pubescent girls." @default.
• W2080474955 created "2016-06-24" @default.
• W2080474955 creator A5021097660 @default.
• W2080474955 creator A5025117351 @default.
• W2080474955 creator A5034451393 @default.
• W2080474955 creator A5077730739 @default.
• W2080474955 date "2011-09-01" @default.
• W2080474955 modified "2023-10-05" @default.
• W2080474955 title "Sex differences in cortisol response to corticotropin releasing hormone challenge over puberty: Pittsburgh Pediatric Neurobehavioral Studies" @default.
• W2080474955 cites W1514751206 @default.
• W2080474955 cites W1554082852 @default.
• W2080474955 cites W1563481933 @default.
• W2080474955 cites W1894125867 @default.
• W2080474955 cites W1964205365 @default.
• W2080474955 cites W1965561480 @default.
• W2080474955 cites W1966656140 @default.
• W2080474955 cites W1966786107 @default.
• W2080474955 cites W1966993479 @default.
• W2080474955 cites W1968476011 @default.
• W2080474955 cites W1971908589 @default.
• W2080474955 cites W1973119983 @default.
• W2080474955 cites W1974702488 @default.
• W2080474955 cites W1975634667 @default.
• W2080474955 cites W1976707838 @default.
• W2080474955 cites W1979958897 @default.
• W2080474955 cites W1981725027 @default.
• W2080474955 cites W1982686484 @default.
• W2080474955 cites W1983544699 @default.
• W2080474955 cites W1985795568 @default.
• W2080474955 cites W1987330686 @default.
• W2080474955 cites W1987708266 @default.
• W2080474955 cites W1988112619 @default.
• W2080474955 cites W1994920740 @default.
• W2080474955 cites W1999504909 @default.
• W2080474955 cites W2003656057 @default.
• W2080474955 cites W2006004036 @default.
• W2080474955 cites W2006770638 @default.
• W2080474955 cites W2007253085 @default.
• W2080474955 cites W2007696393 @default.
• W2080474955 cites W2009908170 @default.
• W2080474955 cites W2012653434 @default.
• W2080474955 cites W2014570372 @default.
• W2080474955 cites W2019147982 @default.
• W2080474955 cites W2022030870 @default.
• W2080474955 cites W2023932614 @default.
• W2080474955 cites W2024551842 @default.
• W2080474955 cites W2025113055 @default.
• W2080474955 cites W2028548963 @default.
• W2080474955 cites W2042473905 @default.
• W2080474955 cites W2044352300 @default.
• W2080474955 cites W2044523195 @default.
• W2080474955 cites W2044819977 @default.
• W2080474955 cites W2048089018 @default.
• W2080474955 cites W2049165791 @default.
• W2080474955 cites W2050414575 @default.
• W2080474955 cites W2050947975 @default.
• W2080474955 cites W2054557267 @default.
• W2080474955 cites W2057462574 @default.
• W2080474955 cites W2058976010 @default.
• W2080474955 cites W2059646524 @default.
• W2080474955 cites W2060032444 @default.
• W2080474955 cites W2062267315 @default.
• W2080474955 cites W2062755250 @default.
• W2080474955 cites W2068991783 @default.
• W2080474955 cites W2069417933 @default.
• W2080474955 cites W2069551547 @default.
• W2080474955 cites W2070085430 @default.
• W2080474955 cites W2070259385 @default.
• W2080474955 cites W2073417859 @default.
• W2080474955 cites W2073521351 @default.
• W2080474955 cites W2074545348 @default.
• W2080474955 cites W2076837989 @default.
• W2080474955 cites W2077572353 @default.
• W2080474955 cites W2077980663 @default.
• W2080474955 cites W2080256190 @default.
• W2080474955 cites W2082569011 @default.
• W2080474955 cites W2086233958 @default.
• W2080474955 cites W2088068432 @default.
• W2080474955 cites W2089694176 @default.
• W2080474955 cites W2091260295 @default.
• W2080474955 cites W2093358121 @default.
• W2080474955 cites W2096829505 @default.
• W2080474955 cites W2097427330 @default.
• W2080474955 cites W2098767958 @default.
• W2080474955 cites W2099303532 @default.
• W2080474955 cites W2110531929 @default.
• W2080474955 cites W2118382063 @default.
• W2080474955 cites W2118826874 @default.
• W2080474955 cites W2119761620 @default.
• W2080474955 cites W2123054324 @default.
• W2080474955 cites W2123367689 @default.
• W2080474955 cites W2124408454 @default.
• W2080474955 cites W2128366895 @default.
• W2080474955 cites W2137190200 @default.
• W2080474955 cites W2137296158 @default.
• W2080474955 cites W2138877746 @default.
• W2080474955 cites W2143629083 @default.
• W2080474955 cites W2159178030 @default.

• next