FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2080475869> ?p ?o ?g. }

• W2080475869 endingPage "17" @default.
• W2080475869 startingPage "5" @default.
• W2080475869 abstract "Aphids exclusively feed on plant phloem sap that contains much sugar and some nonessential amino acids but is poor in lipids and proteins. Conventionally, it has been believed that aphids substantially have no intestinal digestion of proteins. However, we here report an unexpected finding that cysteine protease genes of the family cathepsin B are massively amplified in the lineage of aphids and that many of the protease genes exhibit gut-specific overexpression. By making use of expressed sequence tag data, sequenced cDNAs, and genomic trace sequences of the pea aphid Acyrthosiphon pisum, we identified a total of 28 cathepsin B-like gene copies in the genome of A. pisum. Phylogenetic analyses of all the cathepsin B genes in aphids revealed that genic expansion has continuously proceeded with basal, intermediary, and recent duplications. Estimation of molecular evolutionary rates indicated that major alterations of the rates often occurred after duplications. For example, a gene copy (348) was shown to be slow evolving and close to genes of other insects like Drosophila melanogaster, whereas the other gene copies appeared to have evolved faster with higher ratios of nonsynonymous to synonymous substitutions. We identified a number of gene copies (16 in A. pisum) that contained a replacement at the site required for catalytic activity of the protease. Among these, 2 copies were pseudogenes, whereas the remaining copies were structurally intact and possibly acquired new functions. For example, a cluster of such gene copies (1674) has been subjected to positive selection. Quantitative reverse transcriptase-polymerase chain reaction analyses revealed that the more conserved gene copy (348) showed a constitutive expression, whereas 5 other forms (84, 16, 16D, 1874, and 2744) were preferentially expressed in the gut of A. pisum. Putative biological roles of the diversified cathepsin B-like gene copies in aphids are discussed in relation to their nutritional physiology specialized for plant sap feeding lifestyle." @default.
• W2080475869 created "2016-06-24" @default.
• W2080475869 creator A5005611851 @default.
• W2080475869 creator A5008509797 @default.
• W2080475869 creator A5014840793 @default.
• W2080475869 creator A5015050204 @default.
• W2080475869 creator A5015588754 @default.
• W2080475869 creator A5021143745 @default.
• W2080475869 creator A5038455862 @default.
• W2080475869 creator A5070990956 @default.
• W2080475869 date "2007-11-13" @default.
• W2080475869 modified "2023-10-14" @default.
• W2080475869 title "Large Gene Family Expansion and Variable Selective Pressures for Cathepsin B in Aphids" @default.
• W2080475869 cites W1541329453 @default.
• W2080475869 cites W1568907619 @default.
• W2080475869 cites W1936630560 @default.
• W2080475869 cites W1963604619 @default.
• W2080475869 cites W1971348367 @default.
• W2080475869 cites W1975883081 @default.
• W2080475869 cites W1981708779 @default.
• W2080475869 cites W1994462959 @default.
• W2080475869 cites W2003049026 @default.
• W2080475869 cites W2003061649 @default.
• W2080475869 cites W2009972285 @default.
• W2080475869 cites W2019591778 @default.
• W2080475869 cites W2026977699 @default.
• W2080475869 cites W2035733413 @default.
• W2080475869 cites W2037568077 @default.
• W2080475869 cites W2044247426 @default.
• W2080475869 cites W2048512322 @default.
• W2080475869 cites W2055043387 @default.
• W2080475869 cites W2065012590 @default.
• W2080475869 cites W2069857036 @default.
• W2080475869 cites W2070018377 @default.
• W2080475869 cites W2092033325 @default.
• W2080475869 cites W2092314167 @default.
• W2080475869 cites W2102073250 @default.
• W2080475869 cites W2103196178 @default.
• W2080475869 cites W2103546861 @default.
• W2080475869 cites W2105029969 @default.
• W2080475869 cites W2110324549 @default.
• W2080475869 cites W2117023388 @default.
• W2080475869 cites W2119632499 @default.
• W2080475869 cites W2126116719 @default.
• W2080475869 cites W2130162256 @default.
• W2080475869 cites W2132389001 @default.
• W2080475869 cites W2135123683 @default.
• W2080475869 cites W2137986897 @default.
• W2080475869 cites W2146396346 @default.
• W2080475869 cites W2156509667 @default.
• W2080475869 cites W2156624053 @default.
• W2080475869 cites W2163793049 @default.
• W2080475869 cites W2164789250 @default.
• W2080475869 cites W2166265186 @default.
• W2080475869 doi "https://doi.org/10.1093/molbev/msm222" @default.
• W2080475869 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17934209" @default.
• W2080475869 hasPublicationYear "2007" @default.
• W2080475869 type Work @default.
• W2080475869 sameAs 2080475869 @default.
• W2080475869 citedByCount "73" @default.
• W2080475869 countsByYear W20804758692012 @default.
• W2080475869 countsByYear W20804758692013 @default.
• W2080475869 countsByYear W20804758692015 @default.
• W2080475869 countsByYear W20804758692016 @default.
• W2080475869 countsByYear W20804758692017 @default.
• W2080475869 countsByYear W20804758692018 @default.
• W2080475869 countsByYear W20804758692019 @default.
• W2080475869 countsByYear W20804758692020 @default.
• W2080475869 countsByYear W20804758692022 @default.
• W2080475869 countsByYear W20804758692023 @default.
• W2080475869 crossrefType "journal-article" @default.
• W2080475869 hasAuthorship W2080475869A5005611851 @default.
• W2080475869 hasAuthorship W2080475869A5008509797 @default.
• W2080475869 hasAuthorship W2080475869A5014840793 @default.
• W2080475869 hasAuthorship W2080475869A5015050204 @default.
• W2080475869 hasAuthorship W2080475869A5015588754 @default.
• W2080475869 hasAuthorship W2080475869A5021143745 @default.
• W2080475869 hasAuthorship W2080475869A5038455862 @default.
• W2080475869 hasAuthorship W2080475869A5070990956 @default.
• W2080475869 hasBestOaLocation W20804758691 @default.
• W2080475869 hasConcept C104317684 @default.
• W2080475869 hasConcept C141231307 @default.
• W2080475869 hasConcept C149904235 @default.
• W2080475869 hasConcept C22508944 @default.
• W2080475869 hasConcept C2776385806 @default.
• W2080475869 hasConcept C2776988988 @default.
• W2080475869 hasConcept C2781350953 @default.
• W2080475869 hasConcept C34957205 @default.
• W2080475869 hasConcept C54355233 @default.
• W2080475869 hasConcept C5911399 @default.
• W2080475869 hasConcept C59822182 @default.
• W2080475869 hasConcept C7602840 @default.
• W2080475869 hasConcept C86803240 @default.
• W2080475869 hasConceptScore W2080475869C104317684 @default.
• W2080475869 hasConceptScore W2080475869C141231307 @default.
• W2080475869 hasConceptScore W2080475869C149904235 @default.
• W2080475869 hasConceptScore W2080475869C22508944 @default.
• W2080475869 hasConceptScore W2080475869C2776385806 @default.

• next