Matches in SemOpenAlex for { <https://semopenalex.org/work/W2080478082> ?p ?o ?g. }
Showing items 1 to 97 of
97
with 100 items per page.
- W2080478082 endingPage "896" @default.
- W2080478082 startingPage "896" @default.
- W2080478082 abstract "Recent studies have shown that intracellular signaling pathways, such as the mitogen-activated protein kinases, play a pivotal role in the activation of the inflammatory response. We hypothesized that administration of a specific mitogen-activated protein kinase inhibitor, PD 98059, at the end of resuscitation following severe hemorrhagic shock can reduce the plasma levels of interleukin 6 (IL-6) and hepatocellular damage.Prospective controlled animal study.Medical school-affiliated university hospital.Male Sprague-Dawley (275-325 g) rats underwent laparotomy (ie, soft tissue trauma) and were then bled to a mean arterial pressure of 40 mm Hg for approximately 90 minutes. The animals were then resuscitated with 4 times the bleed-out volume using Ringer lactate solution for 60 minutes. PD 98059, an inhibitor of extracellular signal-regulated kinases (ERKs) 1 and 2 (750 mmol/L), or vehicle (dimethyl sulfoxide and isotonic sodium chloride solution) was administered intravenously as a bolus at the end of resuscitation.At 24 hours after resuscitation or sham operation, plasma levels of IL-6 and alpha-glutathione S-transferase were determined with enzyme-linked immunosorbent assay and enzyme immunoassay, respectively. Moreover liver sections were stained with monoclonal antibody against the phosphorylated form of ERKs.At 24 hours following trauma hemorrhage and resuscitation, plasma levels of IL-6 and alpha-glutathione S-transferase were markedly elevated. Administration of PD 98059, however, reduced levels to sham values. Moreover, liver expression of phosphorylated ERKs was found in the cytosol and nuclear compartment of hepatocytes only following trauma hemorrhage.Administration of PD 98059 (ie, inhibition of intracellular signaling pathways) may represent a feasible approach to blunt the inflammatory response and improve outcome following traumatic injuries and hemorrhagic shock." @default.
- W2080478082 created "2016-06-24" @default.
- W2080478082 creator A5017995838 @default.
- W2080478082 creator A5038627553 @default.
- W2080478082 creator A5057203071 @default.
- W2080478082 creator A5084834018 @default.
- W2080478082 creator A5085171919 @default.
- W2080478082 creator A5087819465 @default.
- W2080478082 date "2004-08-01" @default.
- W2080478082 modified "2023-09-23" @default.
- W2080478082 title "The Effect of Inhibition of a Major Cell Signaling Pathway Following Trauma Hemorrhage on Hepatic Injury and Interleukin 6 Levels" @default.
- W2080478082 cites W1514452974 @default.
- W2080478082 cites W1522814938 @default.
- W2080478082 cites W1972229497 @default.
- W2080478082 cites W1973967947 @default.
- W2080478082 cites W2001977326 @default.
- W2080478082 cites W2002337410 @default.
- W2080478082 cites W2005047699 @default.
- W2080478082 cites W2010180320 @default.
- W2080478082 cites W2012634818 @default.
- W2080478082 cites W2022243058 @default.
- W2080478082 cites W2024279491 @default.
- W2080478082 cites W2026346226 @default.
- W2080478082 cites W2038637041 @default.
- W2080478082 cites W2041981966 @default.
- W2080478082 cites W2045759485 @default.
- W2080478082 cites W2060043509 @default.
- W2080478082 cites W2065166668 @default.
- W2080478082 cites W2070816199 @default.
- W2080478082 cites W2073729932 @default.
- W2080478082 cites W2077635591 @default.
- W2080478082 cites W2079071014 @default.
- W2080478082 cites W2120275497 @default.
- W2080478082 cites W2147481699 @default.
- W2080478082 cites W2163775914 @default.
- W2080478082 cites W2169436115 @default.
- W2080478082 cites W2316274675 @default.
- W2080478082 cites W2343662643 @default.
- W2080478082 cites W71380655 @default.
- W2080478082 cites W608958681 @default.
- W2080478082 doi "https://doi.org/10.1001/archsurg.139.8.896" @default.
- W2080478082 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15302701" @default.
- W2080478082 hasPublicationYear "2004" @default.
- W2080478082 type Work @default.
- W2080478082 sameAs 2080478082 @default.
- W2080478082 citedByCount "22" @default.
- W2080478082 countsByYear W20804780822012 @default.
- W2080478082 countsByYear W20804780822015 @default.
- W2080478082 countsByYear W20804780822016 @default.
- W2080478082 countsByYear W20804780822019 @default.
- W2080478082 countsByYear W20804780822020 @default.
- W2080478082 crossrefType "journal-article" @default.
- W2080478082 hasAuthorship W2080478082A5017995838 @default.
- W2080478082 hasAuthorship W2080478082A5038627553 @default.
- W2080478082 hasAuthorship W2080478082A5057203071 @default.
- W2080478082 hasAuthorship W2080478082A5084834018 @default.
- W2080478082 hasAuthorship W2080478082A5085171919 @default.
- W2080478082 hasAuthorship W2080478082A5087819465 @default.
- W2080478082 hasBestOaLocation W20804780821 @default.
- W2080478082 hasConcept C181199279 @default.
- W2080478082 hasConcept C2778165595 @default.
- W2080478082 hasConcept C42219234 @default.
- W2080478082 hasConcept C538909803 @default.
- W2080478082 hasConcept C55493867 @default.
- W2080478082 hasConcept C71924100 @default.
- W2080478082 hasConcept C86803240 @default.
- W2080478082 hasConcept C98274493 @default.
- W2080478082 hasConceptScore W2080478082C181199279 @default.
- W2080478082 hasConceptScore W2080478082C2778165595 @default.
- W2080478082 hasConceptScore W2080478082C42219234 @default.
- W2080478082 hasConceptScore W2080478082C538909803 @default.
- W2080478082 hasConceptScore W2080478082C55493867 @default.
- W2080478082 hasConceptScore W2080478082C71924100 @default.
- W2080478082 hasConceptScore W2080478082C86803240 @default.
- W2080478082 hasConceptScore W2080478082C98274493 @default.
- W2080478082 hasIssue "8" @default.
- W2080478082 hasLocation W20804780821 @default.
- W2080478082 hasLocation W20804780822 @default.
- W2080478082 hasOpenAccess W2080478082 @default.
- W2080478082 hasPrimaryLocation W20804780821 @default.
- W2080478082 hasRelatedWork W2048660546 @default.
- W2080478082 hasRelatedWork W2052185098 @default.
- W2080478082 hasRelatedWork W2058844431 @default.
- W2080478082 hasRelatedWork W2114534540 @default.
- W2080478082 hasRelatedWork W2125759595 @default.
- W2080478082 hasRelatedWork W2151876548 @default.
- W2080478082 hasRelatedWork W2399636452 @default.
- W2080478082 hasRelatedWork W2471155155 @default.
- W2080478082 hasRelatedWork W2549135832 @default.
- W2080478082 hasRelatedWork W2986915655 @default.
- W2080478082 hasVolume "139" @default.
- W2080478082 isParatext "false" @default.
- W2080478082 isRetracted "false" @default.
- W2080478082 magId "2080478082" @default.
- W2080478082 workType "article" @default.