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- W2080479417 abstract "<h3>Introduction</h3> THE RATIONALE for the use of adrenal steroids in the prevention and treatment of cerebral edema has been based on both experimental studies and clinical observations. Early experimental work<sup>1</sup>showed that steroids could prevent the passage of trypan blue into edematous brain and could help restore a normal electroencephalographic pattern. A clinically smoother postoperative course, reported when patients with craniopharyngiomas were pretreated with steroids,<sup>2,3</sup>was felt to be due to a lessening of postoperative edema. More recent clinical reports have further supported the concept of the usefulness of adrenal steroids in cerebral edema.<sup>4</sup> Prados<sup>1</sup>and more recently Hatanaka<sup>5</sup>have proposed that the steroids act directly on the vascular endothelium of the brain whereas Grenell<sup>6</sup>believed there may be direct action on the cells. A more exact mechanism of action has not been proposed. Indeed, there may be many modes of action of the" @default.
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- W2080479417 date "1965-03-01" @default.
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- W2080479417 title "Effect of Dexamethasone on Mitochondria in Anoxic Brain" @default.
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- W2080479417 doi "https://doi.org/10.1001/archneur.1965.00460270054007" @default.
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