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- W2080481187 startingPage "73" @default.
- W2080481187 abstract "Influenza A viruses (IAVs) remain a major health threat and a prime example of the significance of innate immunity. Our understanding of innate immunity to IAV has grown dramatically, yielding new concepts that change the way we view innate immunity as a whole. Examples include the role of p53, autophagy, microRNA, innate lymphocytes, endothelial cells and gut commensal bacteria in pulmonary innate immunity. Although the innate response is largely beneficial, it also contributes to major complications of IAV, including lung injury, bacterial super-infection and exacerbation of reactive airways disease. Research is beginning to dissect out which components of the innate response are helpful or harmful. IAV uses its limited genetic complement to maximum effect. Several viral proteins are dedicated to combating innate responses, while other viral structural or replication proteins multitask as host immune modulators. Many host innate immune proteins also multitask, having roles in cell cycle, signaling or normal lung biology. We summarize the plethora of new findings and attempt to integrate them into the larger picture of how humans have adapted to the threat posed by this remarkable virus. We explore how our expanded knowledge suggests ways to modulate helpful and harmful inflammatory responses, and develop novel treatments." @default.
- W2080481187 created "2016-06-24" @default.
- W2080481187 creator A5029730540 @default.
- W2080481187 creator A5085018824 @default.
- W2080481187 creator A5089187025 @default.
- W2080481187 date "2013-11-11" @default.
- W2080481187 modified "2023-09-30" @default.
- W2080481187 title "The amazing innate immune response to influenza A virus infection" @default.
- W2080481187 cites W107015691 @default.
- W2080481187 cites W144317117 @default.
- W2080481187 cites W144730948 @default.
- W2080481187 cites W1485359173 @default.
- W2080481187 cites W1487246189 @default.
- W2080481187 cites W1502104604 @default.
- W2080481187 cites W1506913645 @default.
- W2080481187 cites W1512191088 @default.
- W2080481187 cites W1512601207 @default.
- W2080481187 cites W1513080541 @default.
- W2080481187 cites W1521344931 @default.
- W2080481187 cites W1534078836 @default.
- W2080481187 cites W1545910805 @default.
- W2080481187 cites W1552008237 @default.
- W2080481187 cites W1552846692 @default.
- W2080481187 cites W1553440365 @default.
- W2080481187 cites W1575690521 @default.
- W2080481187 cites W1594984016 @default.
- W2080481187 cites W1599612448 @default.
- W2080481187 cites W1606002920 @default.
- W2080481187 cites W1637992308 @default.
- W2080481187 cites W1654674166 @default.
- W2080481187 cites W1792322686 @default.
- W2080481187 cites W1810411573 @default.
- W2080481187 cites W1890971615 @default.
- W2080481187 cites W1896238412 @default.
- W2080481187 cites W1908548782 @default.
- W2080481187 cites W1921818371 @default.
- W2080481187 cites W1932202918 @default.
- W2080481187 cites W1947064939 @default.
- W2080481187 cites W1955500959 @default.
- W2080481187 cites W1959196519 @default.
- W2080481187 cites W1960649778 @default.
- W2080481187 cites W1965188232 @default.
- W2080481187 cites W1965886912 @default.
- W2080481187 cites W1968602018 @default.
- W2080481187 cites W1968750053 @default.
- W2080481187 cites W1969921713 @default.
- W2080481187 cites W1970483947 @default.
- W2080481187 cites W1970604893 @default.
- W2080481187 cites W1970814750 @default.
- W2080481187 cites W1971019498 @default.
- W2080481187 cites W1974626176 @default.
- W2080481187 cites W1975296966 @default.
- W2080481187 cites W1975479248 @default.
- W2080481187 cites W1975757554 @default.
- W2080481187 cites W1976002388 @default.
- W2080481187 cites W1976444162 @default.
- W2080481187 cites W1977142289 @default.
- W2080481187 cites W1977731077 @default.
- W2080481187 cites W1979404155 @default.
- W2080481187 cites W1979441679 @default.
- W2080481187 cites W1980432262 @default.
- W2080481187 cites W1982660013 @default.
- W2080481187 cites W1984783369 @default.
- W2080481187 cites W1985556843 @default.
- W2080481187 cites W1986173321 @default.
- W2080481187 cites W1986426748 @default.
- W2080481187 cites W1988351744 @default.
- W2080481187 cites W1988457839 @default.
- W2080481187 cites W1988677952 @default.
- W2080481187 cites W1990204346 @default.
- W2080481187 cites W1990437594 @default.
- W2080481187 cites W1991051424 @default.
- W2080481187 cites W1991657674 @default.
- W2080481187 cites W1992974015 @default.
- W2080481187 cites W1993054607 @default.
- W2080481187 cites W1993728991 @default.
- W2080481187 cites W1994391392 @default.
- W2080481187 cites W1995509027 @default.
- W2080481187 cites W1997810067 @default.
- W2080481187 cites W1998653357 @default.
- W2080481187 cites W1998846885 @default.
- W2080481187 cites W1999305622 @default.
- W2080481187 cites W1999765884 @default.
- W2080481187 cites W2000451599 @default.
- W2080481187 cites W2001240175 @default.
- W2080481187 cites W2001788095 @default.
- W2080481187 cites W2002406225 @default.
- W2080481187 cites W2003072311 @default.
- W2080481187 cites W2003988251 @default.
- W2080481187 cites W2005928242 @default.
- W2080481187 cites W2006328907 @default.
- W2080481187 cites W2006425559 @default.
- W2080481187 cites W2006862221 @default.
- W2080481187 cites W2007100673 @default.
- W2080481187 cites W2007608885 @default.
- W2080481187 cites W2008075099 @default.
- W2080481187 cites W2008308371 @default.
- W2080481187 cites W2008713419 @default.