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- W2080481491 abstract "Waves of epileptiform activity in neocortex have three phenomenological stages: initiation, propagation, and termination. We use a well studied model of epileptiform activity in vitro to investigate directly the hypothesis that each stage is governed by an independent mechanism within the underlying cortical circuit. Using the partially disinhibited neocortical slice preparation, activity is induced and modulated using neurotransmitter receptor antagonists and is measured using both intracellular recordings and a linear array of extracellular electrodes. We find that initiation depends on both synaptic excitation and inhibition and entails a slow process of recruitment at discrete spatial locations within cortical layer 5 but not layer 2/3. Propagation depends on synaptic excitation but not inhibition and is a fast process that involves neurons across the spatial extent of the slice and in all cortical layers. Termination is modulated by synaptic excitation and inhibition. In space, termination occurs reliably at discrete locations. In time, termination is characterized by a strong depolarizing shift (block) and recovery of neurons in all cortical layers. These results suggest that the phenomenological stages of epileptiform events correspond to distinct mechanistic stages." @default.
- W2080481491 created "2016-06-24" @default.
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- W2080481491 date "2005-09-07" @default.
- W2080481491 modified "2023-09-29" @default.
- W2080481491 title "Initiation, Propagation, and Termination of Epileptiform Activity in Rodent Neocortex<i>In Vitro</i>Involve Distinct Mechanisms" @default.
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- W2080481491 doi "https://doi.org/10.1523/jneurosci.2278-05.2005" @default.
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