Matches in SemOpenAlex for { <https://semopenalex.org/work/W2080485297> ?p ?o ?g. }
- W2080485297 endingPage "311" @default.
- W2080485297 startingPage "304" @default.
- W2080485297 abstract "Evidence obtained in recent years indicates that, in cardiac myocytes, release of Ca(2+) from the sarcoplasmic reticulum (SR) is regulated by changes in the concentration of Ca(2+) within the SR. In this review, we summarize recent advances in our understanding of this regulatory role, with a particular emphasis on dynamic and local changes in SR [Ca(2+)]. We focus on five important questions that are to some extent unresolved and controversial. These questions concern: (1) the importance of SR [Ca(2+)] depletion in the termination of Ca(2+) release; (2) the quantitative extent of depletion during local release events such as Ca(2+) sparks; (3) the influence of SR [Ca(2+)] refilling on release refractoriness and the propensity for pathological Ca(2+) release; (4) dynamic changes in SR [Ca(2+)] during propagating Ca(2+) waves; and (5) the speed of Ca(2+) diffusion within the SR. With each issue, we discuss data supporting alternative viewpoints, and we identify fundamental questions that are being actively investigated. We conclude with a discussion of experimental and computational advances that will help to resolve controversies. This article is part of a special issue entitled Local Signaling in Myocytes." @default.
- W2080485297 created "2016-06-24" @default.
- W2080485297 creator A5000485841 @default.
- W2080485297 creator A5055899029 @default.
- W2080485297 date "2012-02-01" @default.
- W2080485297 modified "2023-09-25" @default.
- W2080485297 title "Dynamic local changes in sarcoplasmic reticulum calcium: Physiological and pathophysiological roles" @default.
- W2080485297 cites W1513594647 @default.
- W2080485297 cites W1517993017 @default.
- W2080485297 cites W1556577169 @default.
- W2080485297 cites W1603273596 @default.
- W2080485297 cites W1857532475 @default.
- W2080485297 cites W1963573758 @default.
- W2080485297 cites W1964683921 @default.
- W2080485297 cites W1965139977 @default.
- W2080485297 cites W1972134881 @default.
- W2080485297 cites W1973328268 @default.
- W2080485297 cites W1974171267 @default.
- W2080485297 cites W1975641338 @default.
- W2080485297 cites W1976981750 @default.
- W2080485297 cites W1983707293 @default.
- W2080485297 cites W1983710068 @default.
- W2080485297 cites W1994681182 @default.
- W2080485297 cites W1996615016 @default.
- W2080485297 cites W1999448871 @default.
- W2080485297 cites W2003046582 @default.
- W2080485297 cites W2010874754 @default.
- W2080485297 cites W2012751980 @default.
- W2080485297 cites W2013798123 @default.
- W2080485297 cites W2014094555 @default.
- W2080485297 cites W2014501709 @default.
- W2080485297 cites W2020183500 @default.
- W2080485297 cites W2021647551 @default.
- W2080485297 cites W2021693681 @default.
- W2080485297 cites W2029620282 @default.
- W2080485297 cites W2042571900 @default.
- W2080485297 cites W2043276871 @default.
- W2080485297 cites W2043712914 @default.
- W2080485297 cites W2046526051 @default.
- W2080485297 cites W2048961320 @default.
- W2080485297 cites W2050824263 @default.
- W2080485297 cites W2050956829 @default.
- W2080485297 cites W2052891859 @default.
- W2080485297 cites W2053995036 @default.
- W2080485297 cites W2054225000 @default.
- W2080485297 cites W2059094476 @default.
- W2080485297 cites W2061535052 @default.
- W2080485297 cites W2067779503 @default.
- W2080485297 cites W2069230499 @default.
- W2080485297 cites W2069644707 @default.
- W2080485297 cites W2071780396 @default.
- W2080485297 cites W2073442720 @default.
- W2080485297 cites W2073472013 @default.
- W2080485297 cites W2075402097 @default.
- W2080485297 cites W2077731194 @default.
- W2080485297 cites W2078734388 @default.
- W2080485297 cites W2080484314 @default.
- W2080485297 cites W2086817408 @default.
- W2080485297 cites W2087941444 @default.
- W2080485297 cites W2089936541 @default.
- W2080485297 cites W2090116945 @default.
- W2080485297 cites W2090362748 @default.
- W2080485297 cites W2096183879 @default.
- W2080485297 cites W2097593721 @default.
- W2080485297 cites W2099121752 @default.
- W2080485297 cites W2099955498 @default.
- W2080485297 cites W2101742222 @default.
- W2080485297 cites W2102807963 @default.
- W2080485297 cites W2103400105 @default.
- W2080485297 cites W2105034692 @default.
- W2080485297 cites W2106800106 @default.
- W2080485297 cites W2107088261 @default.
- W2080485297 cites W2109665703 @default.
- W2080485297 cites W2110997367 @default.
- W2080485297 cites W2111394029 @default.
- W2080485297 cites W2113183554 @default.
- W2080485297 cites W2114329647 @default.
- W2080485297 cites W2114438447 @default.
- W2080485297 cites W2119159332 @default.
- W2080485297 cites W2123976659 @default.
- W2080485297 cites W2126948036 @default.
- W2080485297 cites W2127542820 @default.
- W2080485297 cites W2129115366 @default.
- W2080485297 cites W2133963004 @default.
- W2080485297 cites W2134791820 @default.
- W2080485297 cites W2135436186 @default.
- W2080485297 cites W2140660269 @default.
- W2080485297 cites W2140661076 @default.
- W2080485297 cites W2141207095 @default.
- W2080485297 cites W2147490386 @default.
- W2080485297 cites W2149826121 @default.
- W2080485297 cites W2151082859 @default.
- W2080485297 cites W2151909975 @default.
- W2080485297 cites W2154038686 @default.
- W2080485297 cites W2154620339 @default.
- W2080485297 cites W2154974121 @default.
- W2080485297 cites W2159777565 @default.
- W2080485297 cites W2161023180 @default.