Matches in SemOpenAlex for { <https://semopenalex.org/work/W2080486203> ?p ?o ?g. }
Showing items 1 to 99 of
99
with 100 items per page.
- W2080486203 endingPage "111" @default.
- W2080486203 startingPage "109" @default.
- W2080486203 abstract "Exposure of B-lineage lymphoid cells to ionizing radiation induces an elevation of c-jun proto-oncogene mRNA levels. This signal is abrogated by protein-tyrosine kinase (PTK) inhibitors, indicating that activation of an as yet unidentified PTK is mandatory for radiation-induced c-jun expression. Here, we provide experimental evidence that the cytoplasmic tyrosine kinases BTK, SYK, and LYN are not required for this signal. Lymphoma B-cells rendered deficient for LYN, SYK, or both by targeted gene disruption showed increased c-jun expression levels after radiation exposure, but the magnitude of the stimulation was lower than in wild-type cells. Thus, these PTKs may participate in the generation of an optimal signal. Notably, an inhibitor of JAK-3 (Janus family kinase-3) abrogated radiation-induced c-jun activation, prompting the hypothesis that a chicken homologue of JAK-3 may play a key role in initiation of the radiation-induced c-jun signal in B-lineage lymphoid cells." @default.
- W2080486203 created "2016-06-24" @default.
- W2080486203 creator A5007886970 @default.
- W2080486203 creator A5012790096 @default.
- W2080486203 creator A5025875477 @default.
- W2080486203 creator A5037489081 @default.
- W2080486203 creator A5049101249 @default.
- W2080486203 creator A5075389362 @default.
- W2080486203 date "1997-07-01" @default.
- W2080486203 modified "2023-10-16" @default.
- W2080486203 title "JAK3 Maps to Human Chromosome 19p12 within a Cluster of Proto-oncogenes and Transcription Factors" @default.
- W2080486203 cites W1966493601 @default.
- W2080486203 cites W1972178824 @default.
- W2080486203 cites W1973815940 @default.
- W2080486203 cites W1997785224 @default.
- W2080486203 cites W1999647556 @default.
- W2080486203 cites W2007806597 @default.
- W2080486203 cites W2012408584 @default.
- W2080486203 cites W2014215007 @default.
- W2080486203 cites W2035426895 @default.
- W2080486203 cites W2038705787 @default.
- W2080486203 cites W2046239409 @default.
- W2080486203 cites W2062222238 @default.
- W2080486203 cites W2065130184 @default.
- W2080486203 cites W2071435696 @default.
- W2080486203 cites W2078105135 @default.
- W2080486203 cites W2084694443 @default.
- W2080486203 cites W2093804554 @default.
- W2080486203 cites W4248606467 @default.
- W2080486203 cites W4361807682 @default.
- W2080486203 doi "https://doi.org/10.1006/geno.1997.4792" @default.
- W2080486203 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9226382" @default.
- W2080486203 hasPublicationYear "1997" @default.
- W2080486203 type Work @default.
- W2080486203 sameAs 2080486203 @default.
- W2080486203 citedByCount "10" @default.
- W2080486203 countsByYear W20804862032012 @default.
- W2080486203 countsByYear W20804862032020 @default.
- W2080486203 crossrefType "journal-article" @default.
- W2080486203 hasAuthorship W2080486203A5007886970 @default.
- W2080486203 hasAuthorship W2080486203A5012790096 @default.
- W2080486203 hasAuthorship W2080486203A5025875477 @default.
- W2080486203 hasAuthorship W2080486203A5037489081 @default.
- W2080486203 hasAuthorship W2080486203A5049101249 @default.
- W2080486203 hasAuthorship W2080486203A5075389362 @default.
- W2080486203 hasBestOaLocation W20804862032 @default.
- W2080486203 hasConcept C104317684 @default.
- W2080486203 hasConcept C112392421 @default.
- W2080486203 hasConcept C153911025 @default.
- W2080486203 hasConcept C175818844 @default.
- W2080486203 hasConcept C184235292 @default.
- W2080486203 hasConcept C2779087070 @default.
- W2080486203 hasConcept C35174551 @default.
- W2080486203 hasConcept C42362537 @default.
- W2080486203 hasConcept C502942594 @default.
- W2080486203 hasConcept C54355233 @default.
- W2080486203 hasConcept C62478195 @default.
- W2080486203 hasConcept C86339819 @default.
- W2080486203 hasConcept C86803240 @default.
- W2080486203 hasConcept C90059517 @default.
- W2080486203 hasConcept C95444343 @default.
- W2080486203 hasConceptScore W2080486203C104317684 @default.
- W2080486203 hasConceptScore W2080486203C112392421 @default.
- W2080486203 hasConceptScore W2080486203C153911025 @default.
- W2080486203 hasConceptScore W2080486203C175818844 @default.
- W2080486203 hasConceptScore W2080486203C184235292 @default.
- W2080486203 hasConceptScore W2080486203C2779087070 @default.
- W2080486203 hasConceptScore W2080486203C35174551 @default.
- W2080486203 hasConceptScore W2080486203C42362537 @default.
- W2080486203 hasConceptScore W2080486203C502942594 @default.
- W2080486203 hasConceptScore W2080486203C54355233 @default.
- W2080486203 hasConceptScore W2080486203C62478195 @default.
- W2080486203 hasConceptScore W2080486203C86339819 @default.
- W2080486203 hasConceptScore W2080486203C86803240 @default.
- W2080486203 hasConceptScore W2080486203C90059517 @default.
- W2080486203 hasConceptScore W2080486203C95444343 @default.
- W2080486203 hasIssue "1" @default.
- W2080486203 hasLocation W20804862031 @default.
- W2080486203 hasLocation W20804862032 @default.
- W2080486203 hasLocation W20804862033 @default.
- W2080486203 hasOpenAccess W2080486203 @default.
- W2080486203 hasPrimaryLocation W20804862031 @default.
- W2080486203 hasRelatedWork W1481677180 @default.
- W2080486203 hasRelatedWork W1496101665 @default.
- W2080486203 hasRelatedWork W1945380293 @default.
- W2080486203 hasRelatedWork W1965476653 @default.
- W2080486203 hasRelatedWork W1982411778 @default.
- W2080486203 hasRelatedWork W2133000384 @default.
- W2080486203 hasRelatedWork W2789446032 @default.
- W2080486203 hasRelatedWork W2979714583 @default.
- W2080486203 hasRelatedWork W4229916947 @default.
- W2080486203 hasRelatedWork W4327933233 @default.
- W2080486203 hasVolume "43" @default.
- W2080486203 isParatext "false" @default.
- W2080486203 isRetracted "false" @default.
- W2080486203 magId "2080486203" @default.
- W2080486203 workType "article" @default.