FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2080487249> ?p ?o ?g. }

• W2080487249 endingPage "429" @default.
• W2080487249 startingPage "421" @default.
• W2080487249 abstract "CHRNA4, the gene that encodes the nicotinic acetylcholine receptor α(4) subunit, is a potential candidate gene for nicotine dependence (ND). However, studies of the association of CHNRA4 with smoking behavior have shown inconsistent results. Our meta-analysis of linkage studies of smoking behavior identified a genome-wide significant linkage of the phenotype maximum number of cigarettes smoked in a 24-hour period to a region (20q13.12-q13.32) harboring CHRNA4. This motivated us to examine the association of CHRNA4 with smoking behavior in two independent samples. In this study, we examined five single nucleotide polymorphisms (SNPs) within CHRNA4 and three smoking-related behaviors: one quantitative trait [cigarettes smoked per day (CPD)], and two binary traits [DSM-IV diagnosis of ND and dichotomized Fagerstrom test of ND (FTND)], in 1,249 unrelated European-Americans (EAs) and 1,790 unrelated African-Americans (AAs). Using the combined sample with sex, age, and race as covariates, the synonymous SNP rs1044394 was significantly associated with ND (P = 0.001) and FTND (P = 0.01). Rs2236196, which has a low correlation with rs1044394, was also significantly associated with CPD (P = 0.003). The pattern of association for these SNPs was similar in AAs and EAs. After correction for multiple testing, the association between rs1044394 and ND in the combined sample remained significant (P = 0.033). In summary, our study supports association between CHRNA4 common variation and ND in AA and EA samples. Additional studies will be necessary to evaluate the role of rare variants at CHRNA4 for ND." @default.
• W2080487249 created "2016-06-24" @default.
• W2080487249 creator A5006266154 @default.
• W2080487249 creator A5044047568 @default.
• W2080487249 creator A5050905822 @default.
• W2080487249 creator A5067161403 @default.
• W2080487249 creator A5075420771 @default.
• W2080487249 creator A5075961872 @default.
• W2080487249 date "2011-03-28" @default.
• W2080487249 modified "2023-10-10" @default.
• W2080487249 title "Association of CHRNA4 polymorphisms with smoking behavior in two populations" @default.
• W2080487249 cites W1511621596 @default.
• W2080487249 cites W1530705493 @default.
• W2080487249 cites W1963820730 @default.
• W2080487249 cites W1971088375 @default.
• W2080487249 cites W1971781729 @default.
• W2080487249 cites W1978005528 @default.
• W2080487249 cites W1985349781 @default.
• W2080487249 cites W1996838604 @default.
• W2080487249 cites W2008175710 @default.
• W2080487249 cites W2026049415 @default.
• W2080487249 cites W2027323167 @default.
• W2080487249 cites W2033787363 @default.
• W2080487249 cites W2034160322 @default.
• W2080487249 cites W2052121868 @default.
• W2080487249 cites W2072487099 @default.
• W2080487249 cites W2073702980 @default.
• W2080487249 cites W2098126593 @default.
• W2080487249 cites W2098943613 @default.
• W2080487249 cites W2103093164 @default.
• W2080487249 cites W2103465143 @default.
• W2080487249 cites W2104836142 @default.
• W2080487249 cites W2106472957 @default.
• W2080487249 cites W2110846909 @default.
• W2080487249 cites W2111108162 @default.
• W2080487249 cites W2113778517 @default.
• W2080487249 cites W2117240999 @default.
• W2080487249 cites W2118061336 @default.
• W2080487249 cites W2118082971 @default.
• W2080487249 cites W2118320202 @default.
• W2080487249 cites W2118753748 @default.
• W2080487249 cites W2122791877 @default.
• W2080487249 cites W2123378151 @default.
• W2080487249 cites W2124163128 @default.
• W2080487249 cites W2129331298 @default.
• W2080487249 cites W2132822696 @default.
• W2080487249 cites W2134845797 @default.
• W2080487249 cites W2148998706 @default.
• W2080487249 cites W2152418590 @default.
• W2080487249 cites W2153609942 @default.
• W2080487249 cites W2162106779 @default.
• W2080487249 cites W2166349141 @default.
• W2080487249 cites W4320577279 @default.
• W2080487249 doi "https://doi.org/10.1002/ajmg.b.31177" @default.
• W2080487249 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3742073" @default.
• W2080487249 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21445957" @default.
• W2080487249 hasPublicationYear "2011" @default.
• W2080487249 type Work @default.
• W2080487249 sameAs 2080487249 @default.
• W2080487249 citedByCount "29" @default.
• W2080487249 countsByYear W20804872492012 @default.
• W2080487249 countsByYear W20804872492013 @default.
• W2080487249 countsByYear W20804872492014 @default.
• W2080487249 countsByYear W20804872492015 @default.
• W2080487249 countsByYear W20804872492016 @default.
• W2080487249 countsByYear W20804872492017 @default.
• W2080487249 countsByYear W20804872492018 @default.
• W2080487249 countsByYear W20804872492019 @default.
• W2080487249 countsByYear W20804872492023 @default.
• W2080487249 crossrefType "journal-article" @default.
• W2080487249 hasAuthorship W2080487249A5006266154 @default.
• W2080487249 hasAuthorship W2080487249A5044047568 @default.
• W2080487249 hasAuthorship W2080487249A5050905822 @default.
• W2080487249 hasAuthorship W2080487249A5067161403 @default.
• W2080487249 hasAuthorship W2080487249A5075420771 @default.
• W2080487249 hasAuthorship W2080487249A5075961872 @default.
• W2080487249 hasBestOaLocation W20804872492 @default.
• W2080487249 hasConcept C104317684 @default.
• W2080487249 hasConcept C106208931 @default.
• W2080487249 hasConcept C135763542 @default.
• W2080487249 hasConcept C139275648 @default.
• W2080487249 hasConcept C153209595 @default.
• W2080487249 hasConcept C186413461 @default.
• W2080487249 hasConcept C54355233 @default.
• W2080487249 hasConcept C81941488 @default.
• W2080487249 hasConcept C86803240 @default.
• W2080487249 hasConceptScore W2080487249C104317684 @default.
• W2080487249 hasConceptScore W2080487249C106208931 @default.
• W2080487249 hasConceptScore W2080487249C135763542 @default.
• W2080487249 hasConceptScore W2080487249C139275648 @default.
• W2080487249 hasConceptScore W2080487249C153209595 @default.
• W2080487249 hasConceptScore W2080487249C186413461 @default.
• W2080487249 hasConceptScore W2080487249C54355233 @default.
• W2080487249 hasConceptScore W2080487249C81941488 @default.
• W2080487249 hasConceptScore W2080487249C86803240 @default.
• W2080487249 hasIssue "4" @default.
• W2080487249 hasLocation W20804872491 @default.
• W2080487249 hasLocation W20804872492 @default.

• next