FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2080489322> ?p ?o ?g. }

• W2080489322 endingPage "2174" @default.
• W2080489322 startingPage "2161" @default.
• W2080489322 abstract "All cells of the musculoskeletal system possess transmembrane syndecan proteoglycans, notably syndecan-4. In fibroblasts it regulates integrin-mediated adhesion to the extracellular matrix. Syndecan-4 null mice have a complex wound repair phenotype while their fibroblasts have reduced focal adhesions and matrix contraction abilities. Signalling through syndecan-4 core protein to the actin cytoskeleton involves protein kinase Cα and Rho family G proteins but also direct interactions with α-actinin. The contribution of the latter interaction to cell-matrix adhesion is not defined but investigated here since manipulation of Rho GTPase and its downstream targets could not restore a wild type microfilament organisation to syndecan-4 null cells. Microarray and protein analysis revealed no significant alterations in mRNA or protein levels for actin- or α-actinin associated proteins when wild type and syndecan-4 knockout fibroblasts were compared. The binding site for syndecan-4 cytoplasmic domain was identified as spectrin repeat 4 of α-actinin while further experiments confirmed the importance of this interaction in stabilising cell-matrix junctions. However, α-actinin is also present in adherens junctions, these organelles not being disrupted in the absence of syndecan-4. Indeed, co-culture of wild type and knockout cells led to adherens junction-associated stress fibre formation in cells lacking syndecan-4, supporting the hypothesis that the proteoglycan regulates cell-matrix adhesion and its associated microfilament bundles at a post-translational level. These data provide an additional dimension to syndecan function related to tension at the cell-matrix interface, wound healing and potentially fibrosis." @default.
• W2080489322 created "2016-06-24" @default.
• W2080489322 creator A5023775087 @default.
• W2080489322 creator A5026810159 @default.
• W2080489322 creator A5047144976 @default.
• W2080489322 creator A5051382096 @default.
• W2080489322 creator A5068835269 @default.
• W2080489322 date "2012-12-01" @default.
• W2080489322 modified "2023-10-03" @default.
• W2080489322 title "Alpha-actinin interactions with syndecan-4 are integral to fibroblast–matrix adhesion and regulate cytoskeletal architecture" @default.
• W2080489322 cites W1506343425 @default.
• W2080489322 cites W1529514920 @default.
• W2080489322 cites W1574913479 @default.
• W2080489322 cites W1590696423 @default.
• W2080489322 cites W163314599 @default.
• W2080489322 cites W1744354425 @default.
• W2080489322 cites W1967108732 @default.
• W2080489322 cites W1967928486 @default.
• W2080489322 cites W1968431556 @default.
• W2080489322 cites W1973603507 @default.
• W2080489322 cites W1974377564 @default.
• W2080489322 cites W1979038578 @default.
• W2080489322 cites W1985042934 @default.
• W2080489322 cites W1990939041 @default.
• W2080489322 cites W1993006648 @default.
• W2080489322 cites W1998418462 @default.
• W2080489322 cites W1998715260 @default.
• W2080489322 cites W1999179351 @default.
• W2080489322 cites W2007033032 @default.
• W2080489322 cites W2019085002 @default.
• W2080489322 cites W2024422510 @default.
• W2080489322 cites W2029206521 @default.
• W2080489322 cites W2039425764 @default.
• W2080489322 cites W2041677910 @default.
• W2080489322 cites W2045891730 @default.
• W2080489322 cites W2046203977 @default.
• W2080489322 cites W2050676422 @default.
• W2080489322 cites W2051215009 @default.
• W2080489322 cites W2052712596 @default.
• W2080489322 cites W2057179778 @default.
• W2080489322 cites W2057591881 @default.
• W2080489322 cites W2061600983 @default.
• W2080489322 cites W2069272506 @default.
• W2080489322 cites W2070794132 @default.
• W2080489322 cites W2072871114 @default.
• W2080489322 cites W2093428806 @default.
• W2080489322 cites W2097376134 @default.
• W2080489322 cites W2103048323 @default.
• W2080489322 cites W2103392176 @default.
• W2080489322 cites W2106644177 @default.
• W2080489322 cites W2106923752 @default.
• W2080489322 cites W2120439608 @default.
• W2080489322 cites W2122716387 @default.
• W2080489322 cites W2130837149 @default.
• W2080489322 cites W2141164700 @default.
• W2080489322 cites W2152462023 @default.
• W2080489322 cites W2161754873 @default.
• W2080489322 cites W2307166328 @default.
• W2080489322 doi "https://doi.org/10.1016/j.biocel.2012.08.017" @default.
• W2080489322 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22940199" @default.
• W2080489322 hasPublicationYear "2012" @default.
• W2080489322 type Work @default.
• W2080489322 sameAs 2080489322 @default.
• W2080489322 citedByCount "33" @default.
• W2080489322 countsByYear W20804893222013 @default.
• W2080489322 countsByYear W20804893222014 @default.
• W2080489322 countsByYear W20804893222015 @default.
• W2080489322 countsByYear W20804893222016 @default.
• W2080489322 countsByYear W20804893222017 @default.
• W2080489322 countsByYear W20804893222018 @default.
• W2080489322 countsByYear W20804893222020 @default.
• W2080489322 countsByYear W20804893222021 @default.
• W2080489322 countsByYear W20804893222022 @default.
• W2080489322 countsByYear W20804893222023 @default.
• W2080489322 crossrefType "journal-article" @default.
• W2080489322 hasAuthorship W2080489322A5023775087 @default.
• W2080489322 hasAuthorship W2080489322A5026810159 @default.
• W2080489322 hasAuthorship W2080489322A5047144976 @default.
• W2080489322 hasAuthorship W2080489322A5051382096 @default.
• W2080489322 hasAuthorship W2080489322A5068835269 @default.
• W2080489322 hasConcept C142669718 @default.
• W2080489322 hasConcept C1491633281 @default.
• W2080489322 hasConcept C149402561 @default.
• W2080489322 hasConcept C151166631 @default.
• W2080489322 hasConcept C185592680 @default.
• W2080489322 hasConcept C189165786 @default.
• W2080489322 hasConcept C201508349 @default.
• W2080489322 hasConcept C2777979848 @default.
• W2080489322 hasConcept C2993400109 @default.
• W2080489322 hasConcept C55493867 @default.
• W2080489322 hasConcept C62478195 @default.
• W2080489322 hasConcept C65001120 @default.
• W2080489322 hasConcept C86803240 @default.
• W2080489322 hasConcept C95444343 @default.
• W2080489322 hasConceptScore W2080489322C142669718 @default.
• W2080489322 hasConceptScore W2080489322C1491633281 @default.
• W2080489322 hasConceptScore W2080489322C149402561 @default.
• W2080489322 hasConceptScore W2080489322C151166631 @default.

• next