FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2080489586> ?p ?o ?g. }

• W2080489586 endingPage "290" @default.
• W2080489586 startingPage "279" @default.
• W2080489586 abstract "WEHI-3B D- cells differentiate in response to 1,25-dihydroxyvitamin D3 (1,25-(OH)2D3) but not to all-trans-retinoic acid (RA) or other inducing agents. Combinations of RA with 1,25-(OH)2D3 interact to produce synergistic differentiation of WEHI-3B D- cells. To determine factors involved in the synergistic interaction, expression of the 1,25-(OH)2D3 receptor (VDR) and retinoid receptors, RARalpha and RXRalpha, was measured. No VDR was detected in untreated WEHI-3B D- cells; however, RA and 1,25-(OH)2D3 when used as single agents caused a slight induction of the VDR and in combination produced a marked increase in the VDR. In contrast, no changes in RARalpha and RXRalpha were initiated by these compounds. An RAR-selective agonist combined with 1,25-(OH)2D3 produced synergistic differentiation of WEHI-3B D- cells, whereas an RXR-selective agonist did not. To gain information on the role of the VDR in the synergistic interaction, the VDR gene was transferred into WEHI-3B D+ cells, in which no VDR was detected and no synergism was produced. Expression of the VDR conferred differentiation responsiveness to 1,25-(OH)2D3 in WEHI-3B D+ cells. These findings suggest that (a) induction of VDR expression is a key component in the synergistic differentiation induced by 1,25-(OH)2D3 and RA and (b) RAR and not RXR must be activated for enhanced induction of the VDR and for the synergistic differentiation produced by RA and 1, 25-(OH)2D3." @default.
• W2080489586 created "2016-06-24" @default.
• W2080489586 creator A5043070856 @default.
• W2080489586 creator A5043512123 @default.
• W2080489586 creator A5082820102 @default.
• W2080489586 date "1999-06-01" @default.
• W2080489586 modified "2023-10-14" @default.
• W2080489586 title "Role of Vitamin D3 Receptor in the Synergistic Differentiation of WEHI-3B Leukemia Cells by Vitamin D3 and Retinoic Acid" @default.
• W2080489586 cites W11456762 @default.
• W2080489586 cites W1487178124 @default.
• W2080489586 cites W1495025565 @default.
• W2080489586 cites W1508371220 @default.
• W2080489586 cites W1554600230 @default.
• W2080489586 cites W1579204819 @default.
• W2080489586 cites W1589443505 @default.
• W2080489586 cites W1748624304 @default.
• W2080489586 cites W1969560812 @default.
• W2080489586 cites W1976109625 @default.
• W2080489586 cites W1978854270 @default.
• W2080489586 cites W1980817286 @default.
• W2080489586 cites W1987040411 @default.
• W2080489586 cites W1988290071 @default.
• W2080489586 cites W1988468359 @default.
• W2080489586 cites W1988738875 @default.
• W2080489586 cites W1991853551 @default.
• W2080489586 cites W1992019572 @default.
• W2080489586 cites W2007331929 @default.
• W2080489586 cites W2012571603 @default.
• W2080489586 cites W2020749866 @default.
• W2080489586 cites W2023652470 @default.
• W2080489586 cites W2029466355 @default.
• W2080489586 cites W2036088433 @default.
• W2080489586 cites W2047681882 @default.
• W2080489586 cites W2057773030 @default.
• W2080489586 cites W2072108911 @default.
• W2080489586 cites W2074684677 @default.
• W2080489586 cites W2082198146 @default.
• W2080489586 cites W2082544836 @default.
• W2080489586 cites W2107436981 @default.
• W2080489586 cites W2112823160 @default.
• W2080489586 cites W2117263637 @default.
• W2080489586 cites W2121566707 @default.
• W2080489586 cites W2147868370 @default.
• W2080489586 cites W2197704460 @default.
• W2080489586 cites W2326695791 @default.
• W2080489586 cites W25193327 @default.
• W2080489586 cites W4230033805 @default.
• W2080489586 cites W2114739055 @default.
• W2080489586 doi "https://doi.org/10.1006/excr.1999.4475" @default.
• W2080489586 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10366427" @default.
• W2080489586 hasPublicationYear "1999" @default.
• W2080489586 type Work @default.
• W2080489586 sameAs 2080489586 @default.
• W2080489586 citedByCount "22" @default.
• W2080489586 countsByYear W20804895862012 @default.
• W2080489586 countsByYear W20804895862016 @default.
• W2080489586 countsByYear W20804895862018 @default.
• W2080489586 crossrefType "journal-article" @default.
• W2080489586 hasAuthorship W2080489586A5043070856 @default.
• W2080489586 hasAuthorship W2080489586A5043512123 @default.
• W2080489586 hasAuthorship W2080489586A5082820102 @default.
• W2080489586 hasBestOaLocation W20804895861 @default.
• W2080489586 hasConcept C104317684 @default.
• W2080489586 hasConcept C120197328 @default.
• W2080489586 hasConcept C124490489 @default.
• W2080489586 hasConcept C126322002 @default.
• W2080489586 hasConcept C128821507 @default.
• W2080489586 hasConcept C134018914 @default.
• W2080489586 hasConcept C148738053 @default.
• W2080489586 hasConcept C170493617 @default.
• W2080489586 hasConcept C179639408 @default.
• W2080489586 hasConcept C2775954498 @default.
• W2080489586 hasConcept C2776079296 @default.
• W2080489586 hasConcept C2776940978 @default.
• W2080489586 hasConcept C2778938600 @default.
• W2080489586 hasConcept C2781121885 @default.
• W2080489586 hasConcept C55493867 @default.
• W2080489586 hasConcept C63932345 @default.
• W2080489586 hasConcept C71924100 @default.
• W2080489586 hasConcept C86339819 @default.
• W2080489586 hasConcept C86803240 @default.
• W2080489586 hasConcept C95444343 @default.
• W2080489586 hasConceptScore W2080489586C104317684 @default.
• W2080489586 hasConceptScore W2080489586C120197328 @default.
• W2080489586 hasConceptScore W2080489586C124490489 @default.
• W2080489586 hasConceptScore W2080489586C126322002 @default.
• W2080489586 hasConceptScore W2080489586C128821507 @default.
• W2080489586 hasConceptScore W2080489586C134018914 @default.
• W2080489586 hasConceptScore W2080489586C148738053 @default.
• W2080489586 hasConceptScore W2080489586C170493617 @default.
• W2080489586 hasConceptScore W2080489586C179639408 @default.
• W2080489586 hasConceptScore W2080489586C2775954498 @default.
• W2080489586 hasConceptScore W2080489586C2776079296 @default.
• W2080489586 hasConceptScore W2080489586C2776940978 @default.
• W2080489586 hasConceptScore W2080489586C2778938600 @default.
• W2080489586 hasConceptScore W2080489586C2781121885 @default.
• W2080489586 hasConceptScore W2080489586C55493867 @default.
• W2080489586 hasConceptScore W2080489586C63932345 @default.

• next