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• W2080490018 abstract "While T-cell responses are directly modulated by Toll-like receptor (TLR) ligands, the mechanism and physiological function of nucleic acids (NAs)-mediated T cell costimulation remains unclear. Here we show that unlike in innate cells, T-cell costimulation is induced even by non-CpG DNA and by self-DNA, which is released from dead cells and complexes with antimicrobial peptides or histones. Such NA complexes are internalized by T cells and induce costimulatory responses independently of known NA sensors, including TLRs, RIG-I-like receptors (RLRs), inflammasomes and STING-dependent cytosolic DNA sensors. Such NA-mediated costimulation crucially induces Th2 differentiation by suppressing T-bet expression, followed by the induction of GATA-3 and Th2 cytokines. These findings unveil the function of NA sensing by T cells to trigger and amplify allergic inflammation. Nucleic acids modulate T cell responses; however, the physiological significance of this property remains unclear. Here, the authors show that self-DNA complexes with antimicrobial peptides or histones, which mediates T cell costimulation to induce Th2 cell differentiation." @default.
• W2080490018 created "2016-06-24" @default.
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• W2080490018 date "2014-04-10" @default.
• W2080490018 modified "2023-10-16" @default.
• W2080490018 title "Nucleic acid sensing by T cells initiates Th2 cell differentiation" @default.
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• W2080490018 doi "https://doi.org/10.1038/ncomms4566" @default.
• W2080490018 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24717539" @default.
• W2080490018 hasPublicationYear "2014" @default.
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