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• W2080490063 abstract "Purpose : The aims of this study were to identify the clinical characteristics and determine the changes in the expression of cytokines and apoptosis-related genes in children with infectious mononucleosis. Methods : Serological examinations of 15 pediatric patients diagnosed with infectious mononucleosis were performed pro- spectively. Peripheral blood from the patients was used to compare the composition of T cell subsets, cytokines, Epstein- Barr virus (EBV) DNA, and the expression of apoptosis-related genes with those in 10 healthy children. Results : Mean age of the patient group was 5.7±3.4 (range, 3-9) years, and the male-to-female ratio was 1.5:1. Fever, sore throat, pharyngitis/tonsillitis, and cervical lymph node enlargement were the most common symptoms and signs. The proportions of CD3+ T cells, CD8+ suppressor cells, and CD56+ natural killer (NK) cells were higher in the patient group than in the control group (P<0.01). The IL-2, IL-6, and interferon (IFN)-γ levels were higher in the early symptomatic period (P<0.01). Mean amount of EBV DNA in the patients was 10 2.38 copies/μg, and the amount was the highest at the beginning of the symptomatic period and normalized during the convalescent phase. Bcl-2 expression increased during the initial phase, while Bax expression increased during the convalescent phase. Further, FasL expression increased 1 week after symptom presentation and decreased during the convalescent phase. There was no significant change in Fas expression. Conclusion : We analyzed the clinical characteristics and changes in the expression ofcytokines and apoptosis-related genes in the patients with infectious mononucleosis. (Korean J Pediatr 2009;52:1348-1357)" @default.
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• W2080490063 date "2009-01-01" @default.
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• W2080490063 title "Changes in the expression of cytokines and apoptosis-related genes in children with infectious mononucleosis" @default.
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• W2080490063 doi "https://doi.org/10.3345/kjp.2009.52.12.1348" @default.
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