Matches in SemOpenAlex for { <https://semopenalex.org/work/W2080490643> ?p ?o ?g. }
Showing items 1 to 74 of
74
with 100 items per page.
- W2080490643 endingPage "452" @default.
- W2080490643 startingPage "445" @default.
- W2080490643 abstract "Previous studies in the male rat have demonstrated that GABA acting via GABAB receptors can abolish naloxone-induced LH secretion. The purpose of the present study was to determine if an analogous situation exists in the female rat. Naloxone administered to ovariectomized immature rats had no effect on LH release. In contrast, naloxone potently stimulated LH release in estrogen-primed ovariectomized immature rats. Elevation of endogenous brain levels of GABA by administering amino-oxyacetic acid, an inhibitor of GABA catabolism, prevented the naloxone-stimulated release of LH. This effect appeared to be both GABAA and GABAB receptor mediated, since exogenous administration of either muscimol (GABAA agonist) or baclofen (GABAB agonist) prevented the naloxone-induced release of LH. Neither GABA agonist had any effect on LHRH-stimulated LH release in vivo, suggesting that their effect was specific and achieved at the level of the CNS. In contrast to its inhibitory effect on naloxone-stimulated LH and FSH release, muscimol increased basal LH and FSH release in vivo and from hemipituitaries incubated in vitro, while having no effect on LHRH release from mediobasal hypothalamic and preoptic area fragments in vitro. Thus, under conditions of basal LH release, activation of GABAA receptors in the anterior pituitary can actually lead to enhanced LH secretion. Finally, naloxone-stimulated LH release was found to be inhibited by the alpha 1- and alpha 2-adrenergic blockers, prazosin and yohimbine, suggesting that naloxone-stimulated LH release is mediated via catecholamine neurotransmission involving alpha 1- and alpha 2-adrenergic receptor activation.(ABSTRACT TRUNCATED AT 250 WORDS)" @default.
- W2080490643 created "2016-06-24" @default.
- W2080490643 creator A5007165393 @default.
- W2080490643 creator A5025244311 @default.
- W2080490643 creator A5042701621 @default.
- W2080490643 creator A5047219109 @default.
- W2080490643 date "1992-01-01" @default.
- W2080490643 modified "2023-09-23" @default.
- W2080490643 title "Gamma-Aminobutyric Acid-Opioid Interactions in the Regulation of Gonadotropin Secretion in the Immature Female Rat" @default.
- W2080490643 doi "https://doi.org/10.1159/000126281" @default.
- W2080490643 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1335551" @default.
- W2080490643 hasPublicationYear "1992" @default.
- W2080490643 type Work @default.
- W2080490643 sameAs 2080490643 @default.
- W2080490643 citedByCount "27" @default.
- W2080490643 countsByYear W20804906432012 @default.
- W2080490643 countsByYear W20804906432013 @default.
- W2080490643 countsByYear W20804906432016 @default.
- W2080490643 countsByYear W20804906432018 @default.
- W2080490643 crossrefType "journal-article" @default.
- W2080490643 hasAuthorship W2080490643A5007165393 @default.
- W2080490643 hasAuthorship W2080490643A5025244311 @default.
- W2080490643 hasAuthorship W2080490643A5042701621 @default.
- W2080490643 hasAuthorship W2080490643A5047219109 @default.
- W2080490643 hasConcept C101027131 @default.
- W2080490643 hasConcept C126322002 @default.
- W2080490643 hasConcept C134018914 @default.
- W2080490643 hasConcept C168258287 @default.
- W2080490643 hasConcept C170493617 @default.
- W2080490643 hasConcept C185592680 @default.
- W2080490643 hasConcept C2776885963 @default.
- W2080490643 hasConcept C2777164284 @default.
- W2080490643 hasConcept C2778750930 @default.
- W2080490643 hasConcept C2778938600 @default.
- W2080490643 hasConcept C2779188335 @default.
- W2080490643 hasConcept C71924100 @default.
- W2080490643 hasConcept C8264082 @default.
- W2080490643 hasConcept C86803240 @default.
- W2080490643 hasConceptScore W2080490643C101027131 @default.
- W2080490643 hasConceptScore W2080490643C126322002 @default.
- W2080490643 hasConceptScore W2080490643C134018914 @default.
- W2080490643 hasConceptScore W2080490643C168258287 @default.
- W2080490643 hasConceptScore W2080490643C170493617 @default.
- W2080490643 hasConceptScore W2080490643C185592680 @default.
- W2080490643 hasConceptScore W2080490643C2776885963 @default.
- W2080490643 hasConceptScore W2080490643C2777164284 @default.
- W2080490643 hasConceptScore W2080490643C2778750930 @default.
- W2080490643 hasConceptScore W2080490643C2778938600 @default.
- W2080490643 hasConceptScore W2080490643C2779188335 @default.
- W2080490643 hasConceptScore W2080490643C71924100 @default.
- W2080490643 hasConceptScore W2080490643C8264082 @default.
- W2080490643 hasConceptScore W2080490643C86803240 @default.
- W2080490643 hasIssue "4" @default.
- W2080490643 hasLocation W20804906431 @default.
- W2080490643 hasLocation W20804906432 @default.
- W2080490643 hasOpenAccess W2080490643 @default.
- W2080490643 hasPrimaryLocation W20804906431 @default.
- W2080490643 hasRelatedWork W1983754324 @default.
- W2080490643 hasRelatedWork W1988791946 @default.
- W2080490643 hasRelatedWork W1991514697 @default.
- W2080490643 hasRelatedWork W2026707293 @default.
- W2080490643 hasRelatedWork W2031456054 @default.
- W2080490643 hasRelatedWork W2038456170 @default.
- W2080490643 hasRelatedWork W2052009168 @default.
- W2080490643 hasRelatedWork W2065812602 @default.
- W2080490643 hasRelatedWork W2166448607 @default.
- W2080490643 hasRelatedWork W4237705119 @default.
- W2080490643 hasVolume "56" @default.
- W2080490643 isParatext "false" @default.
- W2080490643 isRetracted "false" @default.
- W2080490643 magId "2080490643" @default.
- W2080490643 workType "article" @default.