Matches in SemOpenAlex for { <https://semopenalex.org/work/W2080491418> ?p ?o ?g. }
Showing items 1 to 88 of
88
with 100 items per page.
- W2080491418 endingPage "538" @default.
- W2080491418 startingPage "533" @default.
- W2080491418 abstract "Linagliptin is a selective, competitive dipeptidyl peptidase-4 (DPP-4) inhibitor, recently approved in the USA, Japan and Europe for the treatment of type 2 diabetes. It has non-linear pharmacokinetics and, unlike other DPP-4 inhibitors, a largely non-renal excretion route. It was hypothesised that P-glycoprotein (P-gp)-mediated intestinal transport could influence linagliptin bioavailability, and might contribute to its elimination. Two studies evaluated the role of P-gp-mediated transport in the bioavailability and intestinal secretion of linagliptin in rats. In the bioavailability study, male Wistar rats received single oral doses of linagliptin, 1 or 15 mg/kg, plus either the P-gp inhibitor, zosuquidar trihydrochloride, or vehicle. For the intestinal secretion study, rats underwent bile duct cannulation, and urine, faeces, and bile were collected. At the end of the study, gut content was sampled. Inhibition of intestinal P-gp increased the bioavailability of orally administered linagliptin, indicating that this transport system plays a role in limiting the uptake of linagliptin from the intestine. This effect was dependent on linagliptin dose, and could play a role in its non-linear pharmacokinetics after oral dosing. Systemically available linagliptin was mainly excreted unchanged via bile (49% of i.v. dose), but some (12%) was also excreted directly into the gut independently of biliary excretion. Thus, direct excretion of linagliptin into the gut may be an alternative excretion route in the presence of liver and renal impairment. The primarily non-renal route of excretion is likely to be of benefit to patients with type 2 diabetes, who have a high prevalence of renal insufficiency." @default.
- W2080491418 created "2016-06-24" @default.
- W2080491418 creator A5016032936 @default.
- W2080491418 creator A5019797384 @default.
- W2080491418 creator A5043548617 @default.
- W2080491418 date "2012-04-01" @default.
- W2080491418 modified "2023-09-26" @default.
- W2080491418 title "Excretion of the dipeptidyl peptidase-4 inhibitor linagliptin in rats is primarily by biliary excretion and P-gp-mediated efflux" @default.
- W2080491418 cites W1980937864 @default.
- W2080491418 cites W1991295934 @default.
- W2080491418 cites W1995020557 @default.
- W2080491418 cites W2000443188 @default.
- W2080491418 cites W2011238752 @default.
- W2080491418 cites W2028648326 @default.
- W2080491418 cites W2059712263 @default.
- W2080491418 cites W2074142099 @default.
- W2080491418 cites W2089291034 @default.
- W2080491418 cites W2096889794 @default.
- W2080491418 cites W2103075451 @default.
- W2080491418 cites W2118186702 @default.
- W2080491418 cites W2123946536 @default.
- W2080491418 cites W2128766821 @default.
- W2080491418 cites W2140480989 @default.
- W2080491418 doi "https://doi.org/10.1016/j.ejps.2011.11.018" @default.
- W2080491418 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22198311" @default.
- W2080491418 hasPublicationYear "2012" @default.
- W2080491418 type Work @default.
- W2080491418 sameAs 2080491418 @default.
- W2080491418 citedByCount "25" @default.
- W2080491418 countsByYear W20804914182012 @default.
- W2080491418 countsByYear W20804914182013 @default.
- W2080491418 countsByYear W20804914182014 @default.
- W2080491418 countsByYear W20804914182015 @default.
- W2080491418 countsByYear W20804914182016 @default.
- W2080491418 countsByYear W20804914182019 @default.
- W2080491418 countsByYear W20804914182020 @default.
- W2080491418 countsByYear W20804914182021 @default.
- W2080491418 countsByYear W20804914182022 @default.
- W2080491418 crossrefType "journal-article" @default.
- W2080491418 hasAuthorship W2080491418A5016032936 @default.
- W2080491418 hasAuthorship W2080491418A5019797384 @default.
- W2080491418 hasAuthorship W2080491418A5043548617 @default.
- W2080491418 hasConcept C10146269 @default.
- W2080491418 hasConcept C112705442 @default.
- W2080491418 hasConcept C126322002 @default.
- W2080491418 hasConcept C134018914 @default.
- W2080491418 hasConcept C181389837 @default.
- W2080491418 hasConcept C185592680 @default.
- W2080491418 hasConcept C2777180221 @default.
- W2080491418 hasConcept C2778763485 @default.
- W2080491418 hasConcept C2780031085 @default.
- W2080491418 hasConcept C555293320 @default.
- W2080491418 hasConcept C71924100 @default.
- W2080491418 hasConcept C98274493 @default.
- W2080491418 hasConceptScore W2080491418C10146269 @default.
- W2080491418 hasConceptScore W2080491418C112705442 @default.
- W2080491418 hasConceptScore W2080491418C126322002 @default.
- W2080491418 hasConceptScore W2080491418C134018914 @default.
- W2080491418 hasConceptScore W2080491418C181389837 @default.
- W2080491418 hasConceptScore W2080491418C185592680 @default.
- W2080491418 hasConceptScore W2080491418C2777180221 @default.
- W2080491418 hasConceptScore W2080491418C2778763485 @default.
- W2080491418 hasConceptScore W2080491418C2780031085 @default.
- W2080491418 hasConceptScore W2080491418C555293320 @default.
- W2080491418 hasConceptScore W2080491418C71924100 @default.
- W2080491418 hasConceptScore W2080491418C98274493 @default.
- W2080491418 hasIssue "5" @default.
- W2080491418 hasLocation W20804914181 @default.
- W2080491418 hasLocation W20804914182 @default.
- W2080491418 hasOpenAccess W2080491418 @default.
- W2080491418 hasPrimaryLocation W20804914181 @default.
- W2080491418 hasRelatedWork W1555144605 @default.
- W2080491418 hasRelatedWork W1970245702 @default.
- W2080491418 hasRelatedWork W1970331292 @default.
- W2080491418 hasRelatedWork W2068691394 @default.
- W2080491418 hasRelatedWork W2080955156 @default.
- W2080491418 hasRelatedWork W2379311614 @default.
- W2080491418 hasRelatedWork W2400119402 @default.
- W2080491418 hasRelatedWork W2606334551 @default.
- W2080491418 hasRelatedWork W2748952813 @default.
- W2080491418 hasRelatedWork W2776273895 @default.
- W2080491418 hasVolume "45" @default.
- W2080491418 isParatext "false" @default.
- W2080491418 isRetracted "false" @default.
- W2080491418 magId "2080491418" @default.
- W2080491418 workType "article" @default.