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- W2080491884 abstract "Abstract The role of putative mediators in the control of thyrotropin (TSH) secretion has been investigated by monitoring hormone release from isolated anterior cells in response to agents and conditions which modify cyclic nucleotide concentrations or calcium fluxes. The secretory response to 5-min pulses of TRH, raised K + concentration and A-23187 was diminished within 5 min when Ca 2+ -free perifusion was begun 80 sec prior to the pulse. In contrast, the response to theophylline and IBMX was unaffected under these conditions. Both IBMX and dibutyryl cyclic AMP potentiated the effects of TRH and raised K + concentration but not that of A-23187. Methoxyverapamil inhibited TSH secretion stimulated by TRH, raised K + concentration and IBMX but not that induced by A-23187. Calcium efflux showed a similar temporal profile to hormone secretion in response to TRH, IBMX and raised K + concentration. It is proposed that one interpretation of these findings is that there is an interrelationship between calcium ions and the cyclic nucleotides in the control of TSH secretion and that cyclic nucleotides may act at the level of the Ca 2+ channel to modulate Ca 2+ entry." @default.
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- W2080491884 date "1978-09-01" @default.
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- W2080491884 title "Studies on the role of calcium and cyclic nucleotides in the control of TSH secretion" @default.
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- W2080491884 doi "https://doi.org/10.1016/0303-7207(78)90012-6" @default.
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