Matches in SemOpenAlex for { <https://semopenalex.org/work/W2080492264> ?p ?o ?g. }
- W2080492264 endingPage "145" @default.
- W2080492264 startingPage "135" @default.
- W2080492264 abstract "Craniosynostosis, a condition that includes the premature fusion of one or multiple cranial sutures, is a relatively common birth defect in humans and the second most common craniofacial anomaly after orofacial clefts. There is a significant clinical variation among different sutural synostoses as well as significant variation within any given single-suture synostosis. Craniosynostosis can be isolated (i.e., nonsyndromic) or occurs as part of a genetic syndrome (e.g., Crouzon, Pfeiffer, Apert, Muenke, and Saethre-Chotzen syndromes). Approximately 85 % of all cases of craniosynostosis are nonsyndromic. Several recent genomic discoveries are elucidating the genetic basis for nonsyndromic cases and implicate the newly identified genes in signaling pathways previously found in syndromic craniosynostosis. Published epidemiologic and phenotypic studies clearly demonstrate that nonsyndromic craniosynostosis is a complex and heterogeneous condition supporting a strong genetic component accompanied by environmental factors that contribute to the pathogenetic network of this birth defect. Large population, rather than single-clinic or hospital-based studies is required with phenotypically homogeneous subsets of patients to further understand the complex genetic, maternal, environmental, and stochastic factors contributing to nonsyndromic craniosynostosis. Learning about these variables is a key in formulating the basis of multidisciplinary and lifelong care for patients with these conditions." @default.
- W2080492264 created "2016-06-24" @default.
- W2080492264 creator A5015648857 @default.
- W2080492264 creator A5038991667 @default.
- W2080492264 creator A5044569718 @default.
- W2080492264 creator A5050508468 @default.
- W2080492264 creator A5091817825 @default.
- W2080492264 date "2014-06-18" @default.
- W2080492264 modified "2023-09-25" @default.
- W2080492264 title "Closing the Gap: Genetic and Genomic Continuum from Syndromic to Nonsyndromic Craniosynostoses" @default.
- W2080492264 cites W1536432298 @default.
- W2080492264 cites W1548385068 @default.
- W2080492264 cites W1571399449 @default.
- W2080492264 cites W1576203165 @default.
- W2080492264 cites W1599453267 @default.
- W2080492264 cites W1607201914 @default.
- W2080492264 cites W162961686 @default.
- W2080492264 cites W177321913 @default.
- W2080492264 cites W1861066543 @default.
- W2080492264 cites W1936740362 @default.
- W2080492264 cites W1963985949 @default.
- W2080492264 cites W1968034624 @default.
- W2080492264 cites W1969654878 @default.
- W2080492264 cites W1971688911 @default.
- W2080492264 cites W1971714543 @default.
- W2080492264 cites W1972462110 @default.
- W2080492264 cites W1973772928 @default.
- W2080492264 cites W1975776102 @default.
- W2080492264 cites W1976421227 @default.
- W2080492264 cites W1980427909 @default.
- W2080492264 cites W1981146437 @default.
- W2080492264 cites W1981155968 @default.
- W2080492264 cites W1981577644 @default.
- W2080492264 cites W1986556367 @default.
- W2080492264 cites W1986671812 @default.
- W2080492264 cites W1988119351 @default.
- W2080492264 cites W1988418842 @default.
- W2080492264 cites W1988804322 @default.
- W2080492264 cites W1988824842 @default.
- W2080492264 cites W1989045574 @default.
- W2080492264 cites W1990207722 @default.
- W2080492264 cites W1994575776 @default.
- W2080492264 cites W1994590448 @default.
- W2080492264 cites W1995277690 @default.
- W2080492264 cites W1995352016 @default.
- W2080492264 cites W1999982116 @default.
- W2080492264 cites W2000224896 @default.
- W2080492264 cites W2001319354 @default.
- W2080492264 cites W2002345411 @default.
- W2080492264 cites W2003392046 @default.
- W2080492264 cites W2003483145 @default.
- W2080492264 cites W2006054408 @default.
- W2080492264 cites W2006700285 @default.
- W2080492264 cites W2009425793 @default.
- W2080492264 cites W2011421080 @default.
- W2080492264 cites W2013100626 @default.
- W2080492264 cites W2016197968 @default.
- W2080492264 cites W2016426924 @default.
- W2080492264 cites W2017203395 @default.
- W2080492264 cites W2021840059 @default.
- W2080492264 cites W2022172325 @default.
- W2080492264 cites W2023833832 @default.
- W2080492264 cites W2024183174 @default.
- W2080492264 cites W2031002289 @default.
- W2080492264 cites W2031011588 @default.
- W2080492264 cites W2031251221 @default.
- W2080492264 cites W2036378143 @default.
- W2080492264 cites W2036641031 @default.
- W2080492264 cites W2036799305 @default.
- W2080492264 cites W2040329227 @default.
- W2080492264 cites W2041371826 @default.
- W2080492264 cites W2042208787 @default.
- W2080492264 cites W2044021006 @default.
- W2080492264 cites W2050362176 @default.
- W2080492264 cites W2054567767 @default.
- W2080492264 cites W2060792848 @default.
- W2080492264 cites W2062798854 @default.
- W2080492264 cites W2062817458 @default.
- W2080492264 cites W2064359236 @default.
- W2080492264 cites W2067416115 @default.
- W2080492264 cites W2067732333 @default.
- W2080492264 cites W2067964671 @default.
- W2080492264 cites W2068306141 @default.
- W2080492264 cites W2068346413 @default.
- W2080492264 cites W2071600778 @default.
- W2080492264 cites W2074110360 @default.
- W2080492264 cites W2074166336 @default.
- W2080492264 cites W2075328770 @default.
- W2080492264 cites W2077045259 @default.
- W2080492264 cites W2077522329 @default.
- W2080492264 cites W2079641984 @default.
- W2080492264 cites W2081691768 @default.
- W2080492264 cites W2090576305 @default.
- W2080492264 cites W2098419019 @default.
- W2080492264 cites W2100021877 @default.
- W2080492264 cites W2104281222 @default.
- W2080492264 cites W2106743030 @default.
- W2080492264 cites W2106950760 @default.