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• W2080493467 abstract "In our previous study, photoprovocation induced lupus erythematosus (LE) and polymorphous light eruption-like lesions in photosensitive LE patients. In this new study we examined the expression of ICAM-1, VCAM-1 and E-selectin, in early lesions in particular. A total of 32 patients with cutaneous LE, 25 with classic discoid LE, and 7 with systemic LE, including 3 patients with subacute cutaneous LE, were provoked with UVA and UVB on normal appearing skin. Induced lesions were followed up with serial biopsies. LE-like histopathology was seen within 1 week of provocation in some cases. Adhesion molecule expression was statistically significantly affected by the factors clinical diagnosis and wavelength (UVA or UVB). Strong keratinocyte ICAM-1 expression was found 1 week after provocation in reactions that eventually developed into long-standing ones. It is possible that these early changes reflect an underlying defect in the mechanisms that regulate adhesion molecule expression in LE." @default.
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• W2080493467 date "1999-10-20" @default.
• W2080493467 modified "2023-10-02" @default.
• W2080493467 title "Early Events in Ultraviolet Light-induced Skin Lesions in Lupus Erythematosus: Expression Patterns of Adhesion Molecules ICAM-1, VCAM-1 and E-selectin" @default.
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• W2080493467 doi "https://doi.org/10.1080/000155599750009852" @default.
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