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• W2080493727 abstract "Fetal hyperinsulinemia in the rat results in increased body weight, lipid content, and enhanced lipogenesis in liver and carcass. The purpose of our study was to determine whether the macrosomia and enhancement of fatty acid (FA) synthesis and/or content persisted postnatally in this animal model. Fetal hyperinsulinemia was produced in Sprague-Dawley rats by injecting fetuses with 2 units of insulin at 20.5 days fo gestation. Alternate pups in the same litter were injected with saline. Pups were delivered surgically at 22.5 days of gestation, were weighed daily and sacrificed on day 15. FA content and synthesis rates of liver and skeletal muscle were measured. We found: (1) At birth, insulin-treated pups were 12% heavier than saline littermates, (5.88 ± 0.14 g v 5.26 ± 0.14 g, P < .01); and (2) The enhanced growth associated with prenatal insulin treatment persisted during the suckling period, ie, compared with saline-treated controls, insulin pups were 15.7% heavier at 15 days of age (P < .01); growth velocity of insulin pups, beginning on day 3, significantly exceeded that of control pups (P < .05). FA contents of liver and muscle in insulin pups, (62.6 ± 5.7 μmol/g and 62.7 ± 13.2 μmol/g) were significantly greater (P < .05) than in saline littermates (45.1 ± 5.6 μmol/g and 30.2 ± 4.7 μmol/g, respectively). We conclude that: (1) Neonatal overgrowth in pups treated prenatally with insulin is not an evanescent condition; and (2) Although elevated FA contents in liver and muscle of insulin-treated pups were observed, the FA synthesis rates in these organs were similar, thus, the precise mechanism for the elevated FA content in these organs remains unclear and needs further investigation." @default.
• W2080493727 created "2016-06-24" @default.
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• W2080493727 date "1985-12-01" @default.
• W2080493727 modified "2023-09-27" @default.
• W2080493727 title "Postnatal growth and fatty acid synthesis in overgrown rat pups induced by fetal hyperinsulinemia" @default.
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• W2080493727 doi "https://doi.org/10.1016/0026-0495(85)90155-6" @default.
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