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- W2080493889 abstract "Slices from rat cerebral cortex incubated in the presence of 2-deoxy[3H]glucose accumulate the sugar mainly in the form of its phosphorylated derivative. 2-Deoxy[3H]glucose uptake, measured under conditions of initial velocity, is stimulated by 50–100% in the presence of depolarising agents (KCl, veratridine) or the excitatory amino acidsl- andd-glutamate, l-aspartate andl-cysteate in millimolar concentrations. In contrast a variety of putative neurotransmitters are ineffective on this test. The stimulations elicited by KCl or excitatory amino acids consist in significant increases in both the apparentKm andFmax values of the 2-deoxyglucose transport system. The effect of excitatory amino acids is not significantly modified in the presence of tetrodotoxin or when the extracellular Ca2+ concentration is diminished, whereas it is significantly reduced in the presence of ouabain. Hence stimulation of 2-deoxy[3H]glucose uptake and phosphorylation may indirectly reflect the activation of Na+, K+-adenosine 5′-triphosphatases triggered by excitatory amino acids in target cells. The stimulation of 2-deoxy[3H[glucose uptake elicited by the three excitatory amino acids is antagonised in an apparently competitive manner by glutamate diethyl ester (apparentKi value of ∼- 15 mM) whereas the KCl-induced stimulation is not modified. In contrast a variety of other amino acid agonists (including quisqualate, kainate, N-methyld-aspartate) or antagonists (including γ-d-glutamyl glycine acid and 2-amino-5-phosphonovalerate) are inactive, indicating that the metabolic response is not mediated by any of the receptor subclasses identified electrophysiologically." @default.
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- W2080493889 date "1984-06-01" @default.
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- W2080493889 title "Stimulation of deoxy[3H]glucose uptake into slices from cerebral cortex elicited by excitatory amino acids" @default.
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- W2080493889 doi "https://doi.org/10.1016/0306-4522(84)90060-5" @default.
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