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• W2080494407 abstract "AFTIR (after flowing through immobilized receptor) is a novel method for screening herbal extracts for pharmaceutical properties. Using AFTIR, we identified Cynarin in Echinacea purpurea by its selective binding to chip immobilized CD28, a receptor of T-cells, which is instrumental to immune functioning. The results of surface plasma resonance show that binding between immobilized CD28 and Cynarin is stronger than the binding between CD28 and CD80, a co-stimulated receptor of antigen presenting cells. Cynarin's function was verified by its ability to downregulate CD28-dependent interleukin-2 (IL-2) expression in a T-cell culture line. AFTIR offers promise as an efficient screening method for herbal medicines." @default.
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• W2080494407 date "2006-02-23" @default.
• W2080494407 modified "2023-10-18" @default.
• W2080494407 title "Immuno-suppressive Effect of Blocking the CD28 Signaling Pathway in T-cells by an Active Component of <i>Echinacea </i>Found by a Novel Pharmaceutical Screening Method" @default.
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• W2080494407 doi "https://doi.org/10.1021/jm0509039" @default.
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