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- W2080494841 abstract "Nuclei from cells having the replicating DNA pulse-labeled with [3H]thymidine and the nonreplicating DNA uniformly labeled with [14C]thymidine were treated with micrococcal nuclease according to procedures which have been used to study the subunit structure of chromatin. Sedimentation analyses of chromatin from nuclease-treated nuclei, together with measurements of the size of newly synthesized DNA, indicate that (1) chromatin subunits near the replication fork are more susceptible to nuclease attack than subunits in non-replicating chromatin; (2) newly synthesized DNA is rapidly assembled into chromatin subunits prior to joining of small DNA replication intermediates; and (3) within 10 min after synthesis, DNA in newly replicated chromatin acquires a susceptibility to nuclease treatment similar to that of non-replicating chromatin." @default.
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- W2080494841 date "1976-11-01" @default.
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- W2080494841 title "Rapid assembly of newly synthesized DNA into chromatin subunits prior to joining of small DNA replication intermediates" @default.
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- W2080494841 doi "https://doi.org/10.1016/0006-291x(76)90510-6" @default.
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