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- W2080494867 abstract "Abstract The OX174 DNA assay system developed earlier is utilized to determine the comparative reactivities with nucleic acid of the diolepoxide metabolites of a series of polycyclic aromatic hydrocarbons varying in carcinogenic potency. The infectious OX174 viral DNA is exposed to the hydrocarbon derivative for 10 min., then infectivity of the treated DNA is assayed by incubation with E. coli spheroplasts, counting plaque formation on agar plates. The bay region diolepoxides of benzo[a]-pyrene, chrysene, and dibenz[a,h]anthracene, implicated as the ultimately active carcinogenic metabolites of the parent hydrocarbons, exhibit potent viral inhibitory activity. On the other hand no correlation is evident between viral inhibitory activity and either the location of the diolepoxide function in a bay region or the theoretically calculated β-delocalization energies (ΔEdeloc.) of the carbonium ion arising from opening the epoxide ring. The significance of these findings with respect to theories of carcinogenesis is discussed." @default.
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- W2080494867 date "1979-05-01" @default.
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- W2080494867 title "Comparative reactivities of diolepoxide metabolites of carcinogenic hydrocarbons with ØX174 viral DNA" @default.
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- W2080494867 doi "https://doi.org/10.1016/0006-291x(79)91723-6" @default.
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