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- W2080495555 abstract "The past two decades have witnessed a major breakthrough in the treatment of cardiac arrhythmias. Owing to technical perfection of implantable cardioverter defibrillators (ICD), antitachycardic pacing (ATP), and radiofrequency catheter ablation, today's treatment of cardiac arrhythmias has reached an unprecedented level of efficacy and safety. At the same time, the use of antiarrhythmic drugs has declined because of their low efficacy and proarrhythmic potential.Do we actually need new antiarrhythmic compounds in the era of ICDs and percutaneous ablation? If the answer is yes, many additional questions come up: Which pharmacological targets should be modified? Are we merely looking for greater efficacy and safety in conventional antiarrhythmic principles [1] or do we need conceptually new approaches? Clearly, the therapeutic goals and the methods by which they are achieved differ in ventricular and in atrial tachyarrhythmias (Fig. 1).Fig. 1 Schematic presentation of the relative importance (indicated by the size of the circles) of the therapeutic options for conversion of ventricular (VT/VF) and atrial (AF) tachyarrhythmias. While the use of an implantable cardioverter defibrillator (ICD) is unquestionably the therapy of choice for life-threatening ventricular tachyarrhythmias, its combination with ablation, antitachycardic pacing (ATP), and drugs may represent options for reducing the number of delivered shocks. Since atrial arrhythmia does not impose an acute threat to survival, atrial ICDs, though effective, are not acceptable. Therefore, conversion of this arrhythmia is the mainstay for drug therapy or ablation. ATP has been tried but appears to be ineffective.Unless ventricular fibrillation (VF) is effectively terminated, death occurs within a few minutes. Therefore, ICDs are the mainstay among the therapeutic options for ventricular tachyarrhythmias (see Fig. 1). The ICD reduces mortality in patients who have survived a potentially life-threatening arrhythmia but also produces a clear survival benefit when used as primary prevention for sudden cardiac death …" @default.
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- W2080495555 date "2005-12-01" @default.
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- W2080495555 title "Do we need new antiarrhythmic compounds in the era of implantable cardiac devices and percutaneous ablation?" @default.
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- W2080495555 doi "https://doi.org/10.1016/j.cardiores.2005.09.013" @default.
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