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• W2080495923 abstract "In this study, we report BF066, a novel adenine derivative, inhibits platelet activation and thrombosis via the adenosine receptor (A2A) activation and phosphodiesterase (PDE) inhibition. BF066 inhibits platelet aggregation and ATP releasing induced by multiple platelet agonists in a dose-dependent manner. The inhibition of BF066 on ADP-induced aggregation is potentiated by adenosine and can be dramatically antagonized by the A2A antagonist SCH58261. BF066 also inhibits the PDE activity and platelet spreading on fibrinogen. In FeCl3-injured mouse mesenteric arterial thrombosis model, BF066 prevents thrombus formation effectively, similar to clopidogrel. Intriguingly, at dose achieving similar antithrombotic effect compared to clopidogrel, BF066 does not increase bleeding significantly. Taken together, these results suggest that BF066 may be an effective and safe antiplatelet agent targeting both PDE and A2A. Considering the successful use of combined antiplatelet therapy, BF066 may be further developed as a novel dual target antiplatelet agent." @default.
• W2080495923 created "2016-06-24" @default.
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• W2080495923 date "2012-07-16" @default.
• W2080495923 modified "2023-10-18" @default.
• W2080495923 title "BF066, a Novel Dual Target Antiplatelet Agent without Significant Bleeding" @default.
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• W2080495923 doi "https://doi.org/10.1371/journal.pone.0040451" @default.
• W2080495923 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3398006" @default.
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