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- W2080495953 abstract "The lipid composition of purified rabies virus was determined after repliction in Nil 2 hamster fibroblasts grown either in monolayer or in spinner culture. The effect of viral infection on the lipids of both cell populations was also investigated. No qualitative difference appeared in the lipids of the virions obtained from either cell culture, but the viral contents reflected some variation in the lipid patterns of the two host cells. The virus grown in cells maintained in spinner culture exhibited a lipid content and a cholesterol : phospholipid molar ratio significantly lower than those of the virus replicated in cells cultivated in monolayer. Furthermore, both virus populations contained a high amount of ceramide trihexoside, despite the lack of this component in the cells maintained in spinner culture. Since these lipids are structurally involved in the viral envelope, it was suggested that the differences in viral lipid composition might be related to some modifications noticed in the morphological and biological characteristics of the rabies virions grown in each cell population." @default.
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- W2080495953 date "1977-10-01" @default.
- W2080495953 modified "2023-10-18" @default.
- W2080495953 title "Comparison of the lipid composition of rabies virus propagated in nil 2 cells maintained in monolayer versus spinner culture" @default.
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- W2080495953 doi "https://doi.org/10.1016/0005-2760(77)90237-5" @default.
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