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• W2080495978 endingPage "439" @default.
• W2080495978 startingPage "423" @default.
• W2080495978 abstract "Peripheral inflammation evokes functional and biochemical changes in the periphery and spinal cord which result in central sensitization and hypersensitivity. Inhibitory control systems from the rostral ventromedial medulla (RVM) are also activated. The present study investigates whether endogenous kappa-opioid receptor (KOPr) systems contribute to these neuroadaptations. Inflammation was induced by intraplantar injection of complete Freund’s adjuvant (CFA) into one hindpaw. Mechanical and thermal thresholds were determined using the Von Frey and radiant heat tests, respectively. KOPr gene deletion in mice or systemic administration of the long-acting KOPr antagonist, norbinaltorphimine (norBNI) significantly exacerbated mechanical and thermal hypersensitivity of the ipsilateral, inflamed paw. Thermal and mechanical thresholds of the non-inflamed, contralateral hindpaw were unaffected by CFA treatment. However, gene deletion as well as norBNI treatment resulted in mechanical, but not thermal hypersensitivity of the non-inflamed paw. Similar results were obtained when norBNI was administered intrathecally or into the RVM in rats. These data demonstrate a previously unrecognized role of endogenous KOPr systems in inhibiting hyperalgesia during inflammation. Furthermore, they demonstrate that decreased KOPr activity in either the spinal cord or RVM not only enhances mechanical and thermal hyperalgesia of the inflamed limb but also leads to an unmasking of mechanical hyperalgesia at a site remote from inflammation. The differential effects of KOPr antagonism on mechanical versus thermal thresholds for the non-inflamed paw support the notion that distinct neuroanatomical or neurochemical mechanisms modulate the processing of thermal versus mechanical stimuli." @default.
• W2080495978 created "2016-06-24" @default.
• W2080495978 creator A5003344404 @default.
• W2080495978 creator A5009097050 @default.
• W2080495978 creator A5016994339 @default.
• W2080495978 creator A5045595920 @default.
• W2080495978 date "2008-08-31" @default.
• W2080495978 modified "2023-10-07" @default.
• W2080495978 title "Endogenous kappa-opioid receptor systems inhibit hyperalgesia associated with localized peripheral inflammation" @default.
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• W2080495978 doi "https://doi.org/10.1016/j.pain.2008.01.023" @default.

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