FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2080496794> ?p ?o ?g. }

• W2080496794 endingPage "289" @default.
• W2080496794 startingPage "285" @default.
• W2080496794 abstract "Selegiline, a selective inhibitor of monoamine oxidase-B (MAO-B), was one of the first adjunct therapies in clinical neurology. A retrospective analysis of data from patients with Parkinson's disease found a significant increase in survival in those treated with selegiline plus L-dopa compared with L-dopa alone. The mechanism of action of selegiline is complex and cannot be explained solely by its MAO-B inhibitory action. Pretreatment with selegiline can protect neurons against a variety of neurotoxins, such as 1-methyl-4-phenyl-1,2,3,6 tetrahydropyridine (MPTP), 6-hydroxydopamine, N-(2-chloroethyl)-N-ethyl-2-bromobenzylamine (DSP-4), methyl-beta-acetoxyethyl-2-chloroethylamine (AF64A), and 5,6-dihydroxyserotonin, which damage dopaminergic, adrenergic, cholinergic, and sertoninergic neurons, respectively. Selegiline produces an amphetamine-like effect, enhances the release of dopamine, and blocks the reuptake of dopamine. It stimulates gene expression of L-aromatic amino acid decarboxylase, increases striatal phenylethylamine levels, and activates dopamine receptors. Selegiline reduces the production of oxidative radicals, up-regulates superoxide dismutase and catalase, and suppresses nonenzymatic and iron-catalyzed autooxidation of dopamine. Selegiline compensates for loss of target-derived trophic support, delays apoptosis in serum-deprived cells, and blocks apoptosis-related fall in the mitochondrial membrane potential. Most of the aforementioned properties occur independently of selegiline's efficacy to inhibit MAO-B." @default.
• W2080496794 created "2016-06-24" @default.
• W2080496794 creator A5000823655 @default.
• W2080496794 creator A5037148940 @default.
• W2080496794 creator A5055820164 @default.
• W2080496794 creator A5085226245 @default.
• W2080496794 date "2002-01-07" @default.
• W2080496794 modified "2023-10-10" @default.
• W2080496794 title "Neuroprotective actions of selegiline" @default.
• W2080496794 cites W1516230268 @default.
• W2080496794 cites W1954848520 @default.
• W2080496794 cites W1968257988 @default.
• W2080496794 cites W1972928919 @default.
• W2080496794 cites W1975623095 @default.
• W2080496794 cites W1980713196 @default.
• W2080496794 cites W1981238340 @default.
• W2080496794 cites W1991720146 @default.
• W2080496794 cites W1993343324 @default.
• W2080496794 cites W2016336099 @default.
• W2080496794 cites W2018068734 @default.
• W2080496794 cites W2028427953 @default.
• W2080496794 cites W2034550136 @default.
• W2080496794 cites W2037109377 @default.
• W2080496794 cites W2042309442 @default.
• W2080496794 cites W2053085095 @default.
• W2080496794 cites W2053976123 @default.
• W2080496794 cites W2063028041 @default.
• W2080496794 cites W2065483111 @default.
• W2080496794 cites W2068870278 @default.
• W2080496794 cites W2088956313 @default.
• W2080496794 cites W2097001586 @default.
• W2080496794 cites W2100379445 @default.
• W2080496794 cites W2127670282 @default.
• W2080496794 cites W2150781120 @default.
• W2080496794 cites W2156982762 @default.
• W2080496794 cites W2326666136 @default.
• W2080496794 cites W2411905904 @default.
• W2080496794 doi "https://doi.org/10.1002/jnr.10148" @default.
• W2080496794 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11813232" @default.
• W2080496794 hasPublicationYear "2002" @default.
• W2080496794 type Work @default.
• W2080496794 sameAs 2080496794 @default.
• W2080496794 citedByCount "115" @default.
• W2080496794 countsByYear W20804967942012 @default.
• W2080496794 countsByYear W20804967942013 @default.
• W2080496794 countsByYear W20804967942014 @default.
• W2080496794 countsByYear W20804967942015 @default.
• W2080496794 countsByYear W20804967942016 @default.
• W2080496794 countsByYear W20804967942017 @default.
• W2080496794 countsByYear W20804967942018 @default.
• W2080496794 countsByYear W20804967942019 @default.
• W2080496794 countsByYear W20804967942020 @default.
• W2080496794 countsByYear W20804967942021 @default.
• W2080496794 countsByYear W20804967942022 @default.
• W2080496794 countsByYear W20804967942023 @default.
• W2080496794 crossrefType "journal-article" @default.
• W2080496794 hasAuthorship W2080496794A5000823655 @default.
• W2080496794 hasAuthorship W2080496794A5037148940 @default.
• W2080496794 hasAuthorship W2080496794A5055820164 @default.
• W2080496794 hasAuthorship W2080496794A5085226245 @default.
• W2080496794 hasConcept C126322002 @default.
• W2080496794 hasConcept C137183658 @default.
• W2080496794 hasConcept C181199279 @default.
• W2080496794 hasConcept C185592680 @default.
• W2080496794 hasConcept C25498285 @default.
• W2080496794 hasConcept C2776024655 @default.
• W2080496794 hasConcept C2776134090 @default.
• W2080496794 hasConcept C2777193897 @default.
• W2080496794 hasConcept C2778674702 @default.
• W2080496794 hasConcept C2779134260 @default.
• W2080496794 hasConcept C2779734285 @default.
• W2080496794 hasConcept C39398028 @default.
• W2080496794 hasConcept C513476851 @default.
• W2080496794 hasConcept C55493867 @default.
• W2080496794 hasConcept C71924100 @default.
• W2080496794 hasConcept C98274493 @default.
• W2080496794 hasConceptScore W2080496794C126322002 @default.
• W2080496794 hasConceptScore W2080496794C137183658 @default.
• W2080496794 hasConceptScore W2080496794C181199279 @default.
• W2080496794 hasConceptScore W2080496794C185592680 @default.
• W2080496794 hasConceptScore W2080496794C25498285 @default.
• W2080496794 hasConceptScore W2080496794C2776024655 @default.
• W2080496794 hasConceptScore W2080496794C2776134090 @default.
• W2080496794 hasConceptScore W2080496794C2777193897 @default.
• W2080496794 hasConceptScore W2080496794C2778674702 @default.
• W2080496794 hasConceptScore W2080496794C2779134260 @default.
• W2080496794 hasConceptScore W2080496794C2779734285 @default.
• W2080496794 hasConceptScore W2080496794C39398028 @default.
• W2080496794 hasConceptScore W2080496794C513476851 @default.
• W2080496794 hasConceptScore W2080496794C55493867 @default.
• W2080496794 hasConceptScore W2080496794C71924100 @default.
• W2080496794 hasConceptScore W2080496794C98274493 @default.
• W2080496794 hasIssue "3" @default.
• W2080496794 hasLocation W20804967941 @default.
• W2080496794 hasLocation W20804967942 @default.
• W2080496794 hasOpenAccess W2080496794 @default.
• W2080496794 hasPrimaryLocation W20804967941 @default.
• W2080496794 hasRelatedWork W1970679628 @default.

• next