FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2080497631> ?p ?o ?g. }

• W2080497631 endingPage "384" @default.
• W2080497631 startingPage "374" @default.
• W2080497631 abstract "Large scale analysis of gene expression in adipose tissue provides a basis for the identification of novel candidate genes involved in the pathophysiology of obesity. Our goal was to explore gene expression in human adipose tissue at a partial genome scale using DNA array.Labeled cDNA, derived from human adipose tissue poly(A+) RNA, was hybridized to a DNA array containing over 18,000 human expressed sequence-tagged (EST) clones. The results were analyzed by database searches.Homology searches of the 300 EST clones with highest hybridization signals revealed that 145 contained DNA sequences identical to known genes and 79 could be linked to UniGene clusters. Of the 145 identified genes, 136 were nonredundant and subsequently characterized with respect to function and chromosomal localization by searching MEDLINE, UniGene, GeneMap, OMIM, SWISS-PROT, the Genome Database, and the Location Data Base. The identified genes were grouped according to their putative functions; cell/organism defense (9.6%), cell division (5.1%), cell signaling/communication (19.8%), cell structure/motility (12.5%), gene/ protein expression (16.9%), metabolism (16.2%), and unclassified (19.8%). Less than 50% of these genes have previously been reported to be expressed in adipose tissue. The chromosomal localization of 268 genes strongly expressed in adipose tissue showed that their relative abundance was significantly increased on chromosomes 11, 19, and 22 compared to the expected distribution of the same number of random genes.Our study resulted in the identification of numerous genes previously not reported to be expressed in adipose tissue. These results suggest that DNA array is a powerful tool in the search for novel regulatory pathways within adipose tissue on a scale that is not possible using conventional methods." @default.
• W2080497631 created "2016-06-24" @default.
• W2080497631 creator A5041345164 @default.
• W2080497631 creator A5056446861 @default.
• W2080497631 creator A5071907882 @default.
• W2080497631 date "2000-08-01" @default.
• W2080497631 modified "2023-10-18" @default.
• W2080497631 title "Partial Genome Scale Analysis of Gene Expression in Human Adipose Tissue Using DNA Array" @default.
• W2080497631 cites W1549751084 @default.
• W2080497631 cites W1907219612 @default.
• W2080497631 cites W1967053372 @default.
• W2080497631 cites W2021208867 @default.
• W2080497631 cites W2030165415 @default.
• W2080497631 cites W2051138087 @default.
• W2080497631 cites W2052188398 @default.
• W2080497631 cites W2067542122 @default.
• W2080497631 cites W2068719237 @default.
• W2080497631 cites W2094613397 @default.
• W2080497631 cites W2094883982 @default.
• W2080497631 cites W2096158027 @default.
• W2080497631 cites W2107339893 @default.
• W2080497631 cites W2122563474 @default.
• W2080497631 cites W2141683819 @default.
• W2080497631 cites W2142036463 @default.
• W2080497631 cites W2161944247 @default.
• W2080497631 cites W2408913104 @default.
• W2080497631 cites W4293310082 @default.
• W2080497631 cites W4294216491 @default.
• W2080497631 doi "https://doi.org/10.1038/oby.2000.45" @default.
• W2080497631 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10968729" @default.
• W2080497631 hasPublicationYear "2000" @default.
• W2080497631 type Work @default.
• W2080497631 sameAs 2080497631 @default.
• W2080497631 citedByCount "48" @default.
• W2080497631 countsByYear W20804976312012 @default.
• W2080497631 countsByYear W20804976312013 @default.
• W2080497631 countsByYear W20804976312014 @default.
• W2080497631 countsByYear W20804976312015 @default.
• W2080497631 countsByYear W20804976312016 @default.
• W2080497631 countsByYear W20804976312017 @default.
• W2080497631 countsByYear W20804976312020 @default.
• W2080497631 countsByYear W20804976312023 @default.
• W2080497631 crossrefType "journal-article" @default.
• W2080497631 hasAuthorship W2080497631A5041345164 @default.
• W2080497631 hasAuthorship W2080497631A5056446861 @default.
• W2080497631 hasAuthorship W2080497631A5071907882 @default.
• W2080497631 hasConcept C104317684 @default.
• W2080497631 hasConcept C134018914 @default.
• W2080497631 hasConcept C141231307 @default.
• W2080497631 hasConcept C149034497 @default.
• W2080497631 hasConcept C150194340 @default.
• W2080497631 hasConcept C171089720 @default.
• W2080497631 hasConcept C187882448 @default.
• W2080497631 hasConcept C189482833 @default.
• W2080497631 hasConcept C197077220 @default.
• W2080497631 hasConcept C2780330800 @default.
• W2080497631 hasConcept C54355233 @default.
• W2080497631 hasConcept C86803240 @default.
• W2080497631 hasConceptScore W2080497631C104317684 @default.
• W2080497631 hasConceptScore W2080497631C134018914 @default.
• W2080497631 hasConceptScore W2080497631C141231307 @default.
• W2080497631 hasConceptScore W2080497631C149034497 @default.
• W2080497631 hasConceptScore W2080497631C150194340 @default.
• W2080497631 hasConceptScore W2080497631C171089720 @default.
• W2080497631 hasConceptScore W2080497631C187882448 @default.
• W2080497631 hasConceptScore W2080497631C189482833 @default.
• W2080497631 hasConceptScore W2080497631C197077220 @default.
• W2080497631 hasConceptScore W2080497631C2780330800 @default.
• W2080497631 hasConceptScore W2080497631C54355233 @default.
• W2080497631 hasConceptScore W2080497631C86803240 @default.
• W2080497631 hasIssue "5" @default.
• W2080497631 hasLocation W20804976311 @default.
• W2080497631 hasLocation W20804976312 @default.
• W2080497631 hasOpenAccess W2080497631 @default.
• W2080497631 hasPrimaryLocation W20804976311 @default.
• W2080497631 hasRelatedWork W1959154305 @default.
• W2080497631 hasRelatedWork W1969876234 @default.
• W2080497631 hasRelatedWork W2031320376 @default.
• W2080497631 hasRelatedWork W2032180350 @default.
• W2080497631 hasRelatedWork W2094012503 @default.
• W2080497631 hasRelatedWork W2113944710 @default.
• W2080497631 hasRelatedWork W2163118548 @default.
• W2080497631 hasRelatedWork W2254526121 @default.
• W2080497631 hasRelatedWork W2383213425 @default.
• W2080497631 hasRelatedWork W2595476180 @default.
• W2080497631 hasVolume "8" @default.
• W2080497631 isParatext "false" @default.
• W2080497631 isRetracted "false" @default.
• W2080497631 magId "2080497631" @default.
• W2080497631 workType "article" @default.